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Sensing Inflammatio...
Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors
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- Burtscher, Bernhard (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Urbina, Pamela Allison Manco (author)
- Univ Modena & Reggio Emilia, Italy
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- Diacci, Chiara (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Borghi, Simone (author)
- Univ Modena & Reggio Emilia, Italy
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- Pinti, Marcello (author)
- Univ Modena & Reggio Emilia, Italy
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- Cossarizza, Andrea (author)
- Univ Modena & Reggio Emilia, Italy
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- Salvarani, Carlo (author)
- Univ Modena & Reggio Emilia, Italy
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- Berggren, Magnus (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Biscarini, Fabio (author)
- Univ Modena & Reggio Emilia, Italy; Ist Italiano Tecnol, Italy
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- Simon, Daniel (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Bortolotti, Carlo A. (author)
- Univ Modena & Reggio Emilia, Italy
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(creator_code:org_t)
- 2021-08-22
- 2021
- English.
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In: Advanced Healthcare Materials. - : Wiley. - 2192-2640 .- 2192-2659. ; 10:20
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Abstract
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- An overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the fields state-of-the-art technologies-organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)-and their use in sensing cytokines and other proteins associated with inflammation are a particular focus. The overview will include an introduction to current clinical and "gold standard" quantification techniques and their limitations in terms of cost, time, and required infrastructure. A critical review of recent progress with OECT- and EGOFET-based protein biosensors is presented, alongside a discussion onthe future of these technologies in the years and decades ahead. This is especially timely as the world grapples with limited healthcare diagnostics during the Coronavirus disease (COVID-19)pandemic where one of the worst-case scenarios for patients is the "cytokine storm." Clearly, low-cost point-of-care technologies provided by OECTs and EGOFETs can ease the global burden on healthcare systems and support professionals by providing unprecedented wealth of data that can help to monitor disease progression in real time.
Subject headings
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Keyword
- biosensors; cytokines; EGOT; inflammation; organic bioelectronics
Publication and Content Type
- ref (subject category)
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- By the author/editor
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Burtscher, Bernh ...
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Urbina, Pamela A ...
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Diacci, Chiara
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Borghi, Simone
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Pinti, Marcello
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Cossarizza, Andr ...
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show more...
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Salvarani, Carlo
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Berggren, Magnus
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Biscarini, Fabio
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Simon, Daniel
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Bortolotti, Carl ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
- Articles in the publication
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Advanced Healthc ...
- By the university
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Linköping University