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Sensing Inflammatio...
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Burtscher, BernhardLinköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
(author)
Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-08-22
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Wiley,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-178734
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-178734URI
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https://doi.org/10.1002/adhm.202100955DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Funding Agencies|European Unions Horizon 2020 research and innovation program under the Marie Skodowska-Curie Grant [813863]; Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation
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An overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the fields state-of-the-art technologies-organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)-and their use in sensing cytokines and other proteins associated with inflammation are a particular focus. The overview will include an introduction to current clinical and "gold standard" quantification techniques and their limitations in terms of cost, time, and required infrastructure. A critical review of recent progress with OECT- and EGOFET-based protein biosensors is presented, alongside a discussion onthe future of these technologies in the years and decades ahead. This is especially timely as the world grapples with limited healthcare diagnostics during the Coronavirus disease (COVID-19)pandemic where one of the worst-case scenarios for patients is the "cytokine storm." Clearly, low-cost point-of-care technologies provided by OECTs and EGOFETs can ease the global burden on healthcare systems and support professionals by providing unprecedented wealth of data that can help to monitor disease progression in real time.
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Urbina, Pamela Allison MancoUniv Modena & Reggio Emilia, Italy
(author)
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Diacci, ChiaraLinköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten(Swepub:liu)chidi30
(author)
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Borghi, SimoneUniv Modena & Reggio Emilia, Italy
(author)
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Pinti, MarcelloUniv Modena & Reggio Emilia, Italy
(author)
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Cossarizza, AndreaUniv Modena & Reggio Emilia, Italy
(author)
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Salvarani, CarloUniv Modena & Reggio Emilia, Italy
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Berggren, MagnusLinköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten(Swepub:liu)magbe98
(author)
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Biscarini, FabioUniv Modena & Reggio Emilia, Italy; Ist Italiano Tecnol, Italy
(author)
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Simon, DanielLinköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten(Swepub:liu)dansi08
(author)
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Bortolotti, Carlo A.Univ Modena & Reggio Emilia, Italy
(author)
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Linköpings universitetLaboratoriet för organisk elektronik
(creator_code:org_t)
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In:Advanced Healthcare Materials: Wiley10:202192-26402192-2659
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Burtscher, Bernh ...
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Urbina, Pamela A ...
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Diacci, Chiara
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Borghi, Simone
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Pinti, Marcello
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Cossarizza, Andr ...
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Salvarani, Carlo
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Berggren, Magnus
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Biscarini, Fabio
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- NATURAL SCIENCES
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Linköping University