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Combined Methylglyo...
Combined Methylglyoxal Scavenger and Collagen Hydrogel Therapy Prevents Adverse Remodeling and Improves Cardiac Function Post-Myocardial Infarction
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- Cimenci, Cagla Eren (författare)
- Univ Ottawa Heart Inst, Canada; Univ Ottawa, Canada
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- Blackburn, Nick J. R. (författare)
- Univ Ottawa Heart Inst, Canada; Univ Ottawa, Canada
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- Sedlakova, Veronika (författare)
- Univ Ottawa Heart Inst, Canada
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- Pupkaite, Justina (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Univ Ottawa Heart Inst, Canada; Univ Ottawa, Canada
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- Munoz, Marcelo (författare)
- Univ Ottawa Heart Inst, Canada
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- Rotstein, Benjamin H. (författare)
- Univ Ottawa Heart Inst, Canada; Univ Ottawa, Canada
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- Spiegel, David A. (författare)
- Yale Univ, CT 06510 USA
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- Alarcon, Emilio I. (författare)
- Univ Ottawa Heart Inst, Canada; Univ Ottawa, Canada
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- Suuronen, Erik J. (författare)
- Univ Ottawa Heart Inst, Canada; Univ Ottawa, Canada
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(creator_code:org_t)
- 2021-10-12
- 2022
- Engelska.
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Ingår i: Advanced Functional Materials. - : WILEY-V C H VERLAG GMBH. - 1616-301X .- 1616-3028. ; 32:1
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Methylglyoxal (MG) is a highly reactive dicarbonyl and the main precursor of advanced glycation end-products (AGEs). After myocardial infarction (MI), MG-derived AGEs accumulate in the heart and contribute to adverse remodeling and loss of cardiac function. In this study, the flavonoid fisetin, a dicarbonyl scavenger, is used to reduce the negative effects of MG in the post-MI heart. A fisetin-loaded collagen type I hydrogel (fisetin-HG) is injected intramyocardially in mice at 3 h post-MI, and compared to fisetin-alone, hydrogel-alone, or saline treatment. Fisetin-HG treatment increases the level of glyoxalase-1 (the main MG-metabolizing enzyme), reduces MG-AGE accumulation, and decreases oxidative stress in the MI heart, which is associated with smaller scar size and improved cardiac function. Treatment with fisetin-HG also promotes neovascularization and increases the number of pro-healing macrophages in the infarct area, while reducing the number of pro-inflammatory macrophages. Taken together, the results demonstrate that the fisetin-collagen hydrogel therapy can reduce the accumulation and negative effects of MG post-MI. This therapy may be a promising approach to limit adverse cardiac remodeling, prevent damage, and preserve function of the infarcted heart.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- antioxidant; fisetin; injectable hydrogel; methylglyoxal; myocardial infarction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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