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  • Opel, NilsUniv Munster, Germany (author)

Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-07-01
  • CMA-Canadian Medical Association,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-180774
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180774URI
  • https://doi.org/10.1503/jpn.200176DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|German Research Foundation (DFG)German Research Foundation (DFG) [FOR2107 DA1151/5-1, DA1151/5-2, SFB-TRR58]; Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster [Dan3/012/17, SEED 11/19]; NIH/NIMHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [U01 MH110008, R01 MH092301]; NIH/MIMH [U01 MH111826]; Lundbeck FoundationLundbeckfonden
  • Background: Obesity is a frequent somatic comorbidity of major depression, and it has been associated with worse clinical outcomes and brain structural abnormalities. Converging evidence suggests that electroconvulsive therapy (ECT) induces both clinical improvements and increased subcortical grey matter volume in patients with depression. However, it remains unknown whether increased body weight modulates the clinical response and structural neuroplasticity that occur with ECT. Methods: To address this question, we conducted a longitudinal investigation of structural MRI data from the Global ECT-MRI Research Collaboration (GEMRIC) in 223 patients who were experiencing a major depressive episode (10 scanning sites). Structural MRI data were acquired before and after ECT, and we assessed change in subcortical grey matter volume using FreeSurfer and Quarc. Results: Higher body mass index (BMI) was associated with a significantly lower increase in subcortical grey matter volume following ECT. We observed significant negative associations between BMI and change in subcortical grey matter volume, with pronounced effects in the thalamus and putamen, where obese participants showed increases in grey matter volume that were 43.3% and 49.6%, respectively, of the increases found in participants with normal weight. As well, BMI significantly moderated the association between subcortical grey matter volume change and clinical response to ECT. We observed no significant association between BMI and clinical response to ECT. Limitations: Because only baseline BMI values were available, we were unable to study BMI changes during ECT and their potential association with clinical and grey matter volume change. Conclusion: Future studies should take into account the relevance of body weight as a modulator of structural neuroplasticity during ECT treatment and aim to further explore the functional relevance of this novel finding.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Narr, Katherine L.Univ Calif Los Angeles, CA 90024 USA; Univ Calif Los Angeles, CA 90024 USA; Univ Calif Los Angeles, CA 90024 USA (author)
  • Abbott, ChristopherUniv New Mexico, NM 87131 USA (author)
  • Argyelan, MiklosFeintein Inst Med Res, NY USA; Zucker Hillside Hosp, NY USA (author)
  • Espinoza, RandallUniv Calif Los Angeles, CA 90024 USA (author)
  • Emsell, LouiseKatholieke Univ Leuven, Belgium (author)
  • Bouckaert, FilipKatholieke Univ Leuven, Belgium (author)
  • Sienaert, PascalKatholieke Univ Leuven, Belgium (author)
  • Vandenbulcke, MathieuKatholieke Univ Leuven, Belgium (author)
  • Nordanskog, PiaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)piano33 (author)
  • Repple, JonathanUniv Munster, Germany (author)
  • Kavakbasi, ErhanUniv Munster, Germany (author)
  • Jorgensen, Martin B.Rigshosp, Denmark (author)
  • Paulson, Olaf B.Rigshosp, Denmark; Univ Copenhagen, Denmark (author)
  • Hanson, Lars G.Copenhagen Univ Hosp Hvidovre, Denmark; Tech Univ Denmark, Denmark (author)
  • Dols, AnnemiekeGGZ Geest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands (author)
  • van Exel, EricGGZ Geest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands (author)
  • Oudega, Mardien L.GGZ Geest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands (author)
  • Takamiya, AkihiroKeio Univ, Japan (author)
  • Kishimoto, TaishiroKeio Univ, Japan (author)
  • Ousdal, Olga ThereseHaukeland Hosp, Norway (author)
  • Haavik, JanUniv Bergen, Norway; Haukeland Hosp, Norway (author)
  • Hammar, AsaHaukeland Hosp, Norway; Univ Bergen, Norway (author)
  • Oedegaard, Ketil JoachimHaukeland Hosp, Norway; Univ Bergen, Norway (author)
  • Kessler, UteHaukeland Hosp, Norway; Univ Bergen, Norway (author)
  • Bartsch, HaukeUniv Calif San Diego, CA 92093 USA; Haukeland Hosp, Norway (author)
  • Dale, Anders M.Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA USA (author)
  • Baune, Bernhard T.Univ Munster, Germany; Univ Melbourne, Australia; Univ Melbourne, Australia (author)
  • Dannlowski, UdoUniv Munster, Germany (author)
  • Oltedal, LeifUniv Bergen, Norway; Haukeland Hosp, Norway (author)
  • Redlich, RonnyUniv Munster, Germany; Univ Halle, Germany (author)
  • Univ Munster, GermanyUniv Calif Los Angeles, CA 90024 USA; Univ Calif Los Angeles, CA 90024 USA; Univ Calif Los Angeles, CA 90024 USA (creator_code:org_t)

Related titles

  • In:Journal of Psychiatry & Neuroscience: CMA-Canadian Medical Association46:4, s. E418-E4261180-48821488-2434

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