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Clinical and Epidem...
Clinical and Epidemiological Features of Acute Zika Virus Infections in Leon, Nicaragua
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- Bowman, Natalie M. (author)
- Univ North Carolina Chapel Hill, NC 27599 USA
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- Bucardo, Filemon (author)
- Univ Nacl Autonoma Nicaragua Leon, Nicaragua
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- Collins, Matthew H. (author)
- Emory Univ, GA 30033 USA
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- Reyes, Yaoska (author)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Univ Nacl Autonoma Nicaragua Leon, Nicaragua
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- Cuadra, Edwing Centeno (author)
- Univ Nacl Autonoma Nicaragua Leon, Nicaragua
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- Blette, Bryan (author)
- Univ North Carolina atChapelHill, NC 27515 USA
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- Lakshmanane, Premkumar (author)
- Univ N Carolina, NC 27515 USA
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- Guerra, Enrique Paulo (author)
- Univ N Carolina, NC 27515 USA
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- Rubinstein, Rebecca (author)
- Univ N Carolina, NC 27515 USA
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- Liou, Guei-Jiun Alice (author)
- Kansas City Univ, MO USA
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- de Silva, Aravinda M. (author)
- Univ N Carolina, NC 27515 USA
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- Becker-Dreps, Sylvia (author)
- Univ N Carolina, NC 27515 USA; Univ N Carolina, NC 27515 USA
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(creator_code:org_t)
- AMER SOC TROP MED & HYGIENE, 2021
- 2021
- English.
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In: American Journal of Tropical Medicine and Hygiene. - : AMER SOC TROP MED & HYGIENE. - 0002-9637 .- 1476-1645. ; 105:4, s. 924-930
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
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- The American Zika virus (ZIKV) epidemic has highlighted the need to gain a better understanding of this emerging virus. The goal of this study was to describe the clinical symptoms, laboratory findings, and risk factors for symptomatic ZIKV infection in an area with ongoing transmission of other arboviral infections. We recruited patients at least 2 years of age seeking care at public health centers in Leon, Nicaragua, between January 2016 and August 2017, for fever, maculopapular rash, and/or nonsuppurative conjunctivitis with a duration of less than 1 week. A laboratory diagnosis of ZIKV was established using a combination of molecular and serological tests. Clinical and laboratory findings and potential risk factors were compared between participants with and without acute ZIKV infection. Fifty-eight (26%) of the 225 participants included in the analysis were found to have acute ZIKV infection. Pregnancy and reports of previous arboviral infection were associated with a higher risk of ZIKV infection. Rash, conjunctivitis, sore throat, and lower absolute neutrophil counts were associated with acute ZIKV infection. The clinical characteristics and risk factors identified were consistent with those identified by previous studies; however, we found sore throat to be a feature of ZIKV infection. We also found that neutrophil counts were lower in ZIKV-infected subjects. These clinical symptoms and laboratory datamay help clinicians suspect ZIKV infection during future outbreaks.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bowman, Natalie ...
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Bucardo, Filemon
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Collins, Matthew ...
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Reyes, Yaoska
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Cuadra, Edwing C ...
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Blette, Bryan
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show more...
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Lakshmanane, Pre ...
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Guerra, Enrique ...
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Rubinstein, Rebe ...
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Liou, Guei-Jiun ...
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de Silva, Aravin ...
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Becker-Dreps, Sy ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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American Journal ...
- By the university
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Linköping University