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- Söderman, LisaKarolinska Inst, Sweden (author)
Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2021-10-20
- Springer Heidelberg,2022
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-180909
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180909URI
- https://doi.org/10.1007/s00228-021-03234-6DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:147941256URI
Supplementary language notes
- Language:English
- Summary in:English
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- Funding Agencies|Karolinska InstituteKarolinska Institutet; Stockholm County CouncilStockholm County Council [20180306]; AFA insurance [170157]
- Purpose Dysmenorrhea is a common, recurring, painful condition with a global prevalence of 71%. The treatment regime for dysmenorrhea includes hormonal therapies and NSAID, both of which are associated with side effects. A dose of 10 mg melatonin daily has previously been shown to reduce the level of pelvic pain in women with endometriosis. We chose to investigate how this regime, administered during the week of menstruation, would affect women with dysmenorrhea but without any signs of endometriosis, as adjuvant analgesic treatment. Methods Forty participants with severe dysmenorrhea were randomized to either melatonin or placebo, 20 in each group. Our primary outcome was pain measured with numeric rating scale (NRS); a difference of at least 1.3 units between the groups was considered clinically significant. Secondary outcomes were use of analgesics, as well as absenteeism and amount of bleeding. Mixed model was used for statistical analysis. Results Eighteen participants completed the study in the placebo group and 19 in the melatonin group. Mean NRS in the placebo group was 2.45 and 3.18 in the melatonin group, which proved to be statistically, although not clinically significant. Conclusion This randomized, double-blinded, placebo-controlled trial could not show that 10 mg of melatonin given orally at bedtime during the menstrual week had better analgesic effect on dysmenorrhea as compared with placebo. However, no adverse effects were observed.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
- Adjuvant analgesics; Dysmenorrhea; Melatonin; Menstruation; Pelvic pain; RCT
Added entries (persons, corporate bodies, meetings, titles ...)
- Edlund, MånsKarolinska Inst, Sweden (author)
- Böttiger, YlvaLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi(Swepub:liu)ylvbo14 (author)
- Marions, LenaKarolinska Institutet (author)
- Karolinska Inst, SwedenAvdelningen för klinisk kemi och farmakologi (creator_code:org_t)
Related titles
- In:European Journal of Clinical Pharmacology: Springer Heidelberg78:2, s. 191-1960031-69701432-1041
Internet link
- https://liu.diva-portal.org/smash/get/diva2:1609698/FULLTEXT01.pdffulltext:print
- https://link.springer.com/content/pdf/10.1007/s00228-021-03234-6.pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180909
- https://doi.org/10.1007/s00228-021-03234-6
- http://kipublications.ki.se/Default.aspx?queryparsed=id:147941256
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- Söderman, Lisa
- Edlund, Måns
- Böttiger, Ylva
- Marions, Lena
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- Linköping University
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