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Recommendations for the use of COVID-19 vaccines in patients with immune-mediated kidney diseases
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- Kronbichler, Andreas (author)
- Med Univ Innsbruck, Austria; Univ Cambridge, England
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- Anders, Hans-Joachim (author)
- Klinikum Univ, Germany
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- Fernandez-Juarez, Gema Maria (author)
- Hosp Univ Fdn Alcorcon, Spain
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- Floege, Jurgen (author)
- RTWH Aachen Univ Hosp, Germany
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- Goumenos, Dimitrios (author)
- Patras Univ Hosp, Greece
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- Segelmark, Marten (author)
- Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Tesar, Vladimir (author)
- Charles Univ Prague, Czech Republic
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- Turkmen, Kultigin (author)
- Necmettin Erbakan Univ, Turkey
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- van Kooten, Cees (author)
- Leiden Univ, Netherlands
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- Bruchfeld, Annette (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Karolinska Inst, Sweden
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(creator_code:org_t)
- 2021-03-09
- 2021
- English.
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In: Nephrology, Dialysis and Transplantation. - : OXFORD UNIV PRESS. - 0931-0509 .- 1460-2385. ; 36:7, s. 1160-1168
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https://academic.oup...
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https://urn.kb.se/re...
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Abstract
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- Coronavirus disease 2019 (COVID-19) vaccine platforms are becoming available and are the most promising strategy to curb the spread of severe acute respiratory syndrome coronavirus 2 infections. However, numerous uncertainties exist regarding the pros and cons of vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members of the Immunonephrology Working Group of the European Renal Association-European Dialysis and Transplant Association discuss 13 frequently asked questions regarding the safety and efficacy of the most promising vaccine candidates. Post-marketing surveillance should be performed to estimate the rate of vaccine response (humoral and cellular) of different vaccine platforms and disease activity following the administration of COVID-19 vaccines. Some of the candidates induce signalling pathways, which also promote autoimmune kidney diseases, e.g. type I interferons in systemic lupus erythematosus. Efficacy estimates would thus far favour the use of selected COVID-19 vaccines, such as BNT162b2, mRNA-1273 or Gam-COVID-Vac. Humoral immune response after vaccination should be monitored using appropriate assays. Even in the absence of neutralizing antibodies, patients might be protected by a sufficient cellular immune response capable of reducing the severity of COVID-19. A reduced vaccine response after the use of CD20-depleting agents is anticipated and it is particularly important to discuss strategies to improve vaccine response with these patients. Distancing and shielding measures remain important, as not all vaccines fully protect from coronavirus infection. In-depth information about the most pressing vaccine questions is essential to reduce vaccine hesitancy of patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- COVID-19; glomerulonephritis; immunity; immune response; vaccine
Publication and Content Type
- ref (subject category)
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Kronbichler, And ...
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Anders, Hans-Joa ...
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Fernandez-Juarez ...
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Floege, Jurgen
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Goumenos, Dimitr ...
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Segelmark, Marte ...
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Tesar, Vladimir
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Turkmen, Kultigi ...
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van Kooten, Cees
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Bruchfeld, Annet ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Nephrology, Dial ...
- By the university
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Linköping University
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Karolinska Institutet