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Secretor Status Str...
Secretor Status Strongly Influences the Incidence of Symptomatic Norovirus Infection in a Genotype-Dependent Manner in a Nicaraguan Birth Cohort
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- Reyes, Yaoska (author)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Gonzalez, Fredman (author)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Gutierrez, Lester (author)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Blandon, Patricia (author)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Centeno, Edwing (author)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Zepeda, Omar (author)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Toval-Ruiz, Christian (author)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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- Lindesmith, Lisa C. (author)
- Univ N Carolina, NC 27515 USA
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- Baric, Ralph S. (author)
- Univ N Carolina, NC 27515 USA
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- Vielot, Nadja (author)
- Univ N Carolina, NC 27515 USA
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- Diez-Valcarce, Marta (author)
- Ctr Dis Control & Prevent, GA USA; Emory Univ, GA 30322 USA
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- Vinje, Jan (author)
- Ctr Dis Control & Prevent, GA USA
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- Svensson, Lennart (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Karolinska Inst, Sweden
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- Becker-Dreps, Sylvia (author)
- Univ N Carolina, NC 27515 USA; Univ N Carolina, NC 27515 USA
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- Nordgren, Johan (author)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Bucardo, Filemon (author)
- Natl Autonomous Univ Nicaragua Leon, Nicaragua
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(creator_code:org_t)
- 2021-06-15
- 2022
- English.
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In: Journal of Infectious Diseases. - : OXFORD UNIV PRESS INC. - 0022-1899 .- 1537-6613. ; 225:1, s. 105-115
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background. The role of histo-blood group on the burden and severity of norovirus gastroenteritis in young infants has not been well documented. Methods. Norovirus gastroenteritis was assessed in 443 Nicaraguan children followed from birth until 3 years of age. Stool samples were tested for norovirus by reverse-transcription quantitative polymerase chain reaction (RT-qPCR), and histo-blood group antigens (HBGAs) were determined by phenotyping of saliva and blood. Hazard ratios and predictors of norovirus acute gastroenteritis (AGE) outcome stratified by HBGA were estimated using Cox proportional hazards models. Results. Of 1353 AGE episodes experienced by children, 229 (17%) tested positive for norovirus with an overall incidence of 21.9/100 child-years. Secretor children were infected as early as 2 months of age and had a higher incidence of norovirus GII compared to nonsecretor children (15.4 vs 4.1/100 child-years, P = .006). Furthermore, all GII.4 AGE episodes occurred in secretor children. Children infected with GI (adjusted odds ratio [aOR], 0.09 [95% confidence interval {CI}, .02-.33]) or non-GII.4 viruses (aOR, 0.2 [95% CI, .07-.6]) were less likely to have severe AGE compared to GII.4-infected children. Conclusions. Secretor status in children strongly influences the incidence of symptomatic norovirus infection in a genogroup or genotype-dependent manner and provides evidence that clinical severity in children depends on norovirus genotypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- birth cohort; histo-blood group antigens; incidence; Nicaragua; norovirus; secretor
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Reyes, Yaoska
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Gonzalez, Fredma ...
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Gutierrez, Leste ...
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Blandon, Patrici ...
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Centeno, Edwing
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Zepeda, Omar
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Toval-Ruiz, Chri ...
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Lindesmith, Lisa ...
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Baric, Ralph S.
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Vielot, Nadja
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Diez-Valcarce, M ...
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Vinje, Jan
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Svensson, Lennar ...
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Becker-Dreps, Sy ...
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Nordgren, Johan
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Bucardo, Filemon
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Journal of Infec ...
- By the university
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Linköping University
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Karolinska Institutet