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Failure to reach he...
Failure to reach hematopoietic allogenic stem cell transplantation in patients with myelodysplastic syndromes planned for transplantation : a population-based study
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- Lindholm, C. (author)
- Karolinska Inst, Ctr Hematol & Regenerat Med, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden
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- Olofsson, E. (author)
- Karolinska Inst, Ctr Hematol & Regenerat Med, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden
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- Creignou, M. (author)
- Karolinska Inst, Ctr Hematol & Regenerat Med, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden
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- Nilsson, L. (author)
- Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden
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- Garelius, H. Gravdahl (author)
- Sahlgrens Univ Hosp, Sect Hematol & Coagulat, Med, Gothenburg, Sweden
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- Cammenga, Jörg, 1969- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping Univ Hosp, Dept Hematol, BKV, Linköping, Sweden.;Linköping Univ Hosp, CKOC, Linköping, Sweden.;Linköping Univ, Linköping, Sweden
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- Ljungman, P. (author)
- Karolinska Institutet
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- Ejerblad, Elisabeth (author)
- Uppsala universitet,Hematologi,Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
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- Tobiasson, M. (author)
- Karolinska Institutet
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Karolinska Inst, Ctr Hematol & Regenerat Med, Dept Med Huddinge, Stockholm, Sweden;Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden (creator_code:org_t)
- 2022-02-02
- 2022
- English.
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In: Bone Marrow Transplantation. - : Springer Nature. - 0268-3369 .- 1476-5365. ; 57, s. 598-606
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Abstract
Subject headings
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- The only potential cure for patients with myelodysplastic syndrome (MDS) is allogeneic hematopoietic stem cell transplantation (HCT). However, a proportion of patients who are HCT candidates do not finally get transplanted. This population-based study aimed to characterize HCT candidates were attempting to reach HCT fail and to identify causes and risk factors for failure. Data were collected from (1) the national Swedish registry, enrolling 291 transplant candidates between 2009-2018, and (2) Karolinska University Hospital, enrolling 131 transplantation candidates between 2000 and 2018. Twenty-five % (nation-wide) and 22% (Karolinska) failed to reach HCT. Reasons for failure to reach HCT were progressive and refractory disease (47%), no donor identified (22%), identification of comorbidity (18%), and infectious complications (14%). Factors associated with failure to reach HCT were IPSS-R cytogenetic risk-group very poor, mixed MDS/MPN disease, low blast count (0-4.9%), and low hemoglobin levels (<= 7.9 g/dL). Transplanted patients had a longer overall survival (OS) compared to patients who failed to reach transplantation (83 months versus 14 months; p < 0.001). The survival advantage was seen for the IPSS-R risk groups intermediate, high, and very high. This study demonstrated that a high proportion of HCT-candidates fail to reach HCT and underlines the difficulties associated with bridging MDS patients to HCT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lindholm, C.
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Olofsson, E.
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Creignou, M.
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Nilsson, L.
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Garelius, H. Gra ...
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Cammenga, Jörg, ...
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show more...
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Ljungman, P.
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Ejerblad, Elisab ...
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Tobiasson, M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Bone Marrow Tran ...
- By the university
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Linköping University
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Uppsala University
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Karolinska Institutet