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Neural Substrates o...
Neural Substrates of Psychotic Depression : Findings From the Global ECT-MRI Research Collaboration
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- Takamiya, Akihiro (author)
- Keio Univ, Japan; Katholieke Univ Leuven, Belgium
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- Dols, Annemiek (author)
- GGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Emsell, Louise (author)
- Katholieke Univ Leuven, Belgium
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- Abbott, Christopher (author)
- Univ New Mexico, NM 87131 USA
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- Yrondi, Antoine (author)
- Univ Toulouse, France
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- Mas, Carles Soriano (author)
- Bellvitge Biomed Res Inst IDIBELL, Spain; Carlos III Hlth Inst, Spain; Univ Autonoma Barcelona, Spain
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- Jorgensen, Martin Balslev (author)
- Psychiat Ctr Copenhagen, Denmark; Univ Copenhagen, Denmark
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- Nordanskog, Pia, 1971- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping
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- Rhebergen, Didi (author)
- GGZ Centraal, Netherlands
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- van Exel, Eric (author)
- GGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Oudega, Mardien L. (author)
- GGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Bouckaert, Filip (author)
- Katholieke Univ Leuven, Belgium
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- Vandenbulcke, Mathieu (author)
- Katholieke Univ Leuven, Belgium
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- Sienaert, Pascal (author)
- Katholieke Univ Leuven, Belgium
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- Peran, Patrice (author)
- Univ Toulouse, France
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- Cano, Marta (author)
- Carlos III Hlth Inst, Spain; Univ Autonoma Barcelona, Spain; Parc Tauli Univ Hosp, Spain
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- Cardoner, Narcis (author)
- Parc Tauli Univ Hosp, Spain
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- Jorgensen, Anders (author)
- Psychiat Ctr Copenhagen, Denmark; Univ Copenhagen, Denmark
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- Paulson, Olaf B. (author)
- Rigshosp, Denmark
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- Hamilton, Paul J., 1970- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Kämpe, Robin, 1989- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Bruin, Willem (author)
- Amsterdam UMC, Netherlands
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- Bartsch, Hauke (author)
- Haukeland Hosp, Norway; Haukeland Hosp, Norway; Univ Bergen, Norway
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- Ousdal, Olga Therese (author)
- Haukeland Hosp, Norway; Univ Bergen, Norway
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- Kessler, Ute (author)
- Univ Bergen, Norway; Haukeland Hosp, Norway
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- van Wingen, Guido (author)
- Amsterdam UMC, Netherlands
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- Oltedal, Leif (author)
- Haukeland Hosp, Norway; Univ Bergen, Norway
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- Kishimoto, Taishiro (author)
- Keio Univ, Japan
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(creator_code:org_t)
- 2021-10-08
- 2022
- English.
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In: Schizophrenia Bulletin. - : Oxford University Press. - 0586-7614 .- 1745-1701. ; 48:2, s. 514-523
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- psychosis; depression; magnetic resonance imaging; gray matter volume; medial prefrontal cortex
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Takamiya, Akihir ...
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Dols, Annemiek
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Emsell, Louise
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Abbott, Christop ...
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Yrondi, Antoine
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Mas, Carles Sori ...
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show more...
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Jorgensen, Marti ...
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Nordanskog, Pia, ...
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Rhebergen, Didi
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van Exel, Eric
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Oudega, Mardien ...
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Bouckaert, Filip
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Vandenbulcke, Ma ...
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Sienaert, Pascal
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Peran, Patrice
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Cano, Marta
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Cardoner, Narcis
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Jorgensen, Ander ...
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Paulson, Olaf B.
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Hamilton, Paul J ...
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Kämpe, Robin, 19 ...
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Bruin, Willem
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Bartsch, Hauke
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Ousdal, Olga The ...
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Kessler, Ute
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van Wingen, Guid ...
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Oltedal, Leif
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Kishimoto, Taish ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Schizophrenia Bu ...
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Linköping University