Beta 2 -adrenergic receptor gene haplotypes and bronchodilator response in Egyptian patients with chronic obstructive pulmonary disease

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Hussein, Mohammad H.Department of Chest Diseases, Faculty of Medicine, Cairo University, Giza, Egypt; Department of Respiratory Medicine, Jahra Hospital, Kuwait (author)

Beta 2 -adrenergic receptor gene haplotypes and bronchodilator response in Egyptian patients with chronic obstructive pulmonary disease

Article/chapterEnglish2017

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Warsaw, Poland :Elsevier,2017
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LIBRIS-ID:oai:DiVA.org:liu-184321
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184321URI
https://doi.org/10.1016/j.advms.2016.07.008DOI

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Language:English
Summary in:English

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Purpose: Chronic obstructive pulmonary disease (COPD) is a multi-factorial disorder caused by environmental determinants and genetic risk factors. Understanding the genetic predisposition of COPD is essential to develop personalized treatment regimens. Beta2-adrenergic receptor (ADRB2) gene polymorphisms have been implicated in the pathogenesis of obstructive pulmonary diseases. This study was conducted to assess the genetic association between Arg16Gly and Gln27Glu polymorphisms and COPD in the Egyptian patients, and to analyze their impact on the clinical outcome and therapeutic response.Patients/methods: The study population included 115 participants (61 COPD patients and 54 healthy controls) were genotyped for the Arg16Gly (rs1042713) and Gln27Glu (rs1042714) polymorphisms. Pulmonary function test was done and repeated in patients after salbutamol inhalation.Results: The Gly16 and Gln27 alleles represented 57% and 70% of the whole study population, and only 3 haplotypes were detected; Arg16/Gln27, Gly16/Gln27, and Gly16/Glu27. Genotypes and haplotypes homozygous for Arg16 and Gln27 were more likely to develop COPD (p<0.05). However, individuals carrying Glu27 allele conferred protection against COPD development (p=0.002). Furthermore, Arg16 genotypes and haplotypes were significantly associated with higher grades of dyspnea, more COPD symptoms and frequent exacerbations. In contrast, patients carrying Glu27 allele had better bronchial airway responsiveness to β2-agonists.Conclusions: Our findings suggested that the ADRB2 gene polymorphisms may have vital role in COPD risk, severity, and bronchodilator response among Egyptian population. Larger epidemiological studies are needed for results validation.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Bronchodilator response; Egyptian; Single nucleotide polymorphism; qRT-PCR; β(2)-Adrenergic receptor gene

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Sobhy, Khaled E.Department of Chest Diseases, Faculty of Medicine, Cairo University, Giza, Egypt (author)
Sabry, Irene M.Department of Chest Diseases, Faculty of Medicine, Cairo University, Giza, Egypt (author)
El-Serafi, Ahmed Taher,1977-epartment of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt; Basic Medical Sciences Department, University of Sharjah, Sharjah, United Arab Emirates(Swepub:liu)ahmel66 (author)
Toraih, Eman A.Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt (author)
Department of Chest Diseases, Faculty of Medicine, Cairo University, Giza, Egypt; Department of Respiratory Medicine, Jahra Hospital, KuwaitDepartment of Chest Diseases, Faculty of Medicine, Cairo University, Giza, Egypt (creator_code:org_t)

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In:Advances in Medical SciencesWarsaw, Poland : Elsevier62:1, s. 193-2011896-11261898-4002

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By the author/editor: Hussein, Mohamma ...; Sobhy, Khaled E.; Sabry, Irene M.; El-Serafi, Ahmed ...; Toraih, Eman A.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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By the university: Linköping University

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