Search: onr:"swepub:oai:DiVA.org:liu-18470" >
Targeting malignant...
Targeting malignant glioma cells in vitro using platelet-derived growth factor AA-based conjugates
-
- Dahlström Wester, Maria (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
-
- Wasteson, Åke (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
-
- Lindström, Annelie (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
-
(creator_code:org_t)
- 2009-05
- 2009
- English.
-
In: Journal of drug targeting. - : Informa UK Limited. - 1029-2330 .- 1061-186X. ; , s. 1-10
- Related links:
-
http://urn.kb.se/res...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Glioblastoma multiforme (GBM) is an unusually aggressive brain tumor; it is also highly heterogeneous. Poor prognosis and a median survival of less than 1 year, using conventional treatment, calls for development of new treatment strategies. Overexpression and/or amplification of platelet-derived growth factor alpha receptors (PDGFalphaRs) in GBM might act as potential targets for a novel therapeutic approach. In this study, conjugates based on PDGFAA-ligand and dextran, of different sizes (10 and 40 kDa dextran), were prepared and investigated regarding targeting properties in vitro. Three human malignant glioma cell lines, U343MGa31L, U343MGaCl2:6, and U563MG, were used because of their previously reported differences in receptor expression and behavior. PDGFAA-based 10 kDa dextran iodine-125 radiolabeled conjugates showed the most favorable properties according to results achieved in accumulation, retention, and localization of cell-associated radioactivity. In comparison with dextran-(125)I-tyrosine delivered radioactivity, the PDGFAA-based dextran conjugates confirm the potential of receptor targeting.
Keyword
- Conjugate
- dextran
- glioblastoma multiforme
- PDGFAA
- PDGF receptors
- targeting
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database