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Targeting malignant...
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Dahlström Wester, MariaLinköpings universitet,Cellbiologi,Hälsouniversitetet
(author)
Targeting malignant glioma cells in vitro using platelet-derived growth factor AA-based conjugates
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-05
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Informa UK Limited,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-18470
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18470URI
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https://doi.org/10.1080/10611860902718698DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Glioblastoma multiforme (GBM) is an unusually aggressive brain tumor; it is also highly heterogeneous. Poor prognosis and a median survival of less than 1 year, using conventional treatment, calls for development of new treatment strategies. Overexpression and/or amplification of platelet-derived growth factor alpha receptors (PDGFalphaRs) in GBM might act as potential targets for a novel therapeutic approach. In this study, conjugates based on PDGFAA-ligand and dextran, of different sizes (10 and 40 kDa dextran), were prepared and investigated regarding targeting properties in vitro. Three human malignant glioma cell lines, U343MGa31L, U343MGaCl2:6, and U563MG, were used because of their previously reported differences in receptor expression and behavior. PDGFAA-based 10 kDa dextran iodine-125 radiolabeled conjugates showed the most favorable properties according to results achieved in accumulation, retention, and localization of cell-associated radioactivity. In comparison with dextran-(125)I-tyrosine delivered radioactivity, the PDGFAA-based dextran conjugates confirm the potential of receptor targeting.
Subject headings and genre
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Conjugate
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dextran
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glioblastoma multiforme
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PDGFAA
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PDGF receptors
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targeting
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Wasteson, ÅkeLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)akewa07
(author)
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Lindström, AnnelieLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)annli74
(author)
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Linköpings universitetCellbiologi
(creator_code:org_t)
Related titles
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In:Journal of drug targeting: Informa UK Limited, s. 1-101029-23301061-186X
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