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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004592naa a2200517 4500
001oai:DiVA.org:liu-185003
003SwePub
008220517s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1850032 URI
0247 a https://doi.org/10.1007/s10549-022-06600-92 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Sherman, Mark E.u Mayo Clin, FL, USA4 aut
2451 0a Serum hormone levels and normal breast histology among premenopausal women
264 c 2022-05-03
264 1a New York, NY, United States :b Springer,c 2022
338 a print2 rdacarrier
500 a Funding Agencies: Mayo Clinic Cancer Center [P30CA15083-45]
520 a Purpose Breast terminal duct lobular units (TDLUs) are the main source of breast cancer (BC) precursors. Higher serum concentrations of hormones and growth factors have been linked to increased TDLU numbers and to elevated BC risk, with variable effects by menopausal status. We assessed associations of circulating factors with breast histology among premenopausal women using artificial intelligence (AI) and preliminarily tested whether parity modifies associations.Methods Pathology AI analysis was performed on 316 digital images of H&E-stained sections of normal breast tissues from Komen Tissue Bank donors ages ≤ 45 years to assess 11 quantitative metrics. Associations of circulating factors with AI metrics were assessed using regression analyses, with inclusion of interaction terms to assess effect modification.Results Higher prolactin levels were related to larger TDLU area (p<0.001) and increased presence of adipose tissue proximate to TDLUs (p<0.001), with less significant positive associations for acini counts (p = 0.012), dilated acini (p = 0.043), capillary area (p = 0.014), epithelial area (p = 0.007), and mononuclear cell counts (p = 0.017). Testosterone levels were associated with increased TDLU counts (p<0.001), irrespective of parity, but associations differed by adipose tissue content. AI data for TDLU counts generally agreed with prior visual assessments.Conclusion Among premenopausal women, serum hormone levels linked to BC risk were also associated with quantitative features of normal breast tissue. These relationships were suggestively modified by parity status and tissue composition. We conclude that the microanatomic features of normal breast tissue may represent a marker of BC risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Breast cancer risk; Terminal duct lobular units; Hormones; Normal breast tissue
7001 a de Bel, Thomasu Radboud Univ Nijmegen, Netherlands; Radboud Inst Hlth Sci, Netherlands4 aut
7001 a Heckman, Michael G.u Mayo Clin, FL, USA4 aut
7001 a White, Launia J.u Mayo Clin, FL, USA4 aut
7001 a Ogony, Joshuau Mayo Clin, FL, USA4 aut
7001 a Stallings-Mann, Melodyu Mayo Clin, FL, USA4 aut
7001 a Hilton, Tracyu Mayo Clin, FL, USA4 aut
7001 a Degnim, Amy C.u Mayo Clin, MN, USA4 aut
7001 a Vierkant, Robert A.u Mayo Clin, MN, USA4 aut
7001 a Hoskin, Tanyau Mayo Clin, MN, USA4 aut
7001 a Jensen, Matthew R.u Mayo Clin, MN, USA4 aut
7001 a Pacheco-Spann, Laurau Mayo Clin, FL, USA4 aut
7001 a Henry, Jill E.u Indiana Univ Sch Med, IN, USA4 aut
7001 a Storniolo, Anna Mariau Indiana Univ Sch Med, IN, USA4 aut
7001 a Carter, Jodi M.u Mayo Clin, MN 55905 USA4 aut
7001 a Winham, Stacey J.u Mayo Clin, MN, USA4 aut
7001 a Radisky, Derek C.u Mayo Clin, FL, USA4 aut
7001 a van der Laak, Jeroen,d 1967-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Klinisk patologi,Radboud Univ Nijmegen, Netherlands; Radboud Inst Hlth Sci, Netherlands4 aut0 (Swepub:liu)jerva26
7102 a Mayo Clin, FL, USAb Radboud Univ Nijmegen, Netherlands; Radboud Inst Hlth Sci, Netherlands4 org
7730 t Breast Cancer Research and Treatmentd New York, NY, United States : Springerg 194, s. 149-158q 194<149-158x 0167-6806x 1573-7217
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185003
8564 8u https://doi.org/10.1007/s10549-022-06600-9

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