Analysis of the MCTP Amino Acid Sequence Reveals the Conservation of Putative Calcium- and Lipid-Binding Pockets Within the C2 Domains In Silico

Téllez-Arreola, José LuisDepartamento de Neurobiología Celular Y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla, Juriquilla, Querétaro, México (author)

Funding: CONACYT [A1-S-7659, 395834]; PAPIIT-UNAM [IN204520]
MCTPs (Multiple C2 Domains and Transmembrane region Proteins) are evolutionarily and structurally related to other C2 proteins, which are central to exocytosis and membrane trafficking; however, their specific function has been little studied. MCTPs are associated with endosomes and the endoplasmic reticulum and possess three C2 domains (C2A-C2C) and two transmembrane regions (TMRs) well conserved in different species. Here, we generated structural models of the MCTP C2 domains of C. elegans and analyzed their putative function by docking, which revealed that these domains possess Ca2+- and lipid-binding pockets, suggesting that MCTPs play a significant, calcium-dependent role in membrane physiology.

Martínez-Torres, AtaúlfoDepartamento de Neurobiología Celular Y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla, Juriquilla, Querétaro, México (author)
Flores-Moran, Adriana E.Unit for Basic and Applied Microbiology, School of Natural Sciences, Autonomous University of Queretaro, Queretaro, Mexico (author)
Lazaro-Guevara, José M.Department of Human Genetics, University of Utah, Salt Lake City, UT, USA; Department of Botany, University of British Columbia, Vancouver, BC, Canada; Biodiversity Research Centre, University of British Columbia, Vancouver, BC, Canada (author)
Estrada-Mondragon, ArgelLinköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten(Swepub:liu)arges08 (author)
Departamento de Neurobiología Celular Y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla, Juriquilla, Querétaro, MéxicoUnit for Basic and Applied Microbiology, School of Natural Sciences, Autonomous University of Queretaro, Queretaro, Mexico (creator_code:org_t)

In:Journal of Molecular EvolutionNew York, NY, United States : Springer90, s. 271-2820022-28441432-1432

By the author/editor: Téllez-Arreola, ...; Martínez-Torres, ...; Flores-Moran, Ad ...; Lazaro-Guevara, ...; Estrada-Mondrago ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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