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Cerium Oxide Nanopa...
Cerium Oxide Nanoparticles with Entrapped Gadolinium for High T-1 Relaxivity and ROS-Scavenging Purposes
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- Eriksson, Peter (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Truong, Anh H. T. (author)
- Nanyang Technol Univ, Singapore
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- Brommesson, Caroline (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Du Rietz, Anna (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Kokil, Ganesh R. (author)
- Univ Queensland, Australia
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- Boyd, Robert (author)
- Linköpings universitet,Plasma och ytbeläggningsfysik,Tekniska fakulteten
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- Hu, Zhang-Jun (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Dang, Tram T. (author)
- Linköpings universitet,Tunnfilmsfysik,Tekniska fakulteten
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- Persson, Per O A (author)
- Linköpings universitet,Tunnfilmsfysik,Tekniska fakulteten
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- Uvdal, Kajsa (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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(creator_code:org_t)
- 2022-06-07
- 2022
- English.
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In: ACS Omega. - : American Chemical Society (ACS). - 2470-1343. ; 7:24, s. 21337-21345
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Gadolinium chelates are employed worldwide today as clinical contrast agents for magnetic resonance imaging. Until now, the commonly used linear contrast agents based on the rare-earth element gadolinium have been considered safe and well-tolerated. Recently, concerns regarding this type of contrast agent have been reported, which is why there is an urgent need to develop the next generation of stable contrast agents with enhanced spin-lattice relaxation, as measured by improved T-1 relaxivity at lower doses. Here, we show that by the integration of gadolinium ions in cerium oxide nanoparticles, a stable crystalline 5 nm sized nanoparticulate system with a homogeneous gadolinium ion distribution is obtained. These cerium oxide nanoparticles with entrapped gadolinium deliver strong T-1 relaxivity per gadolinium ion (T-1 relaxivity, r(1) = 12.0 mM(-1) s(-1)) with the potential to act as scavengers of reactive oxygen species (ROS). The presence of Ce3+ sites and oxygen vacancies at the surface plays a critical role in providing the antioxidant properties. The characterization of radial distribution of Ce3+ and Ce4+ oxidation states indicated a higher concentration of Ce3+ at the nanoparticle surfaces. Additionally, we investigated the ROS-scavenging capabilities of pure gadolinium-containing cerium oxide nanoparticles by bioluminescent imaging in vivo, where inhibitory effects on ROS activity are shown.
Subject headings
- NATURVETENSKAP -- Kemi -- Oorganisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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ACS Omega
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To the university's database
- By the author/editor
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Eriksson, Peter
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Truong, Anh H. T ...
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Brommesson, Caro ...
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Du Rietz, Anna
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Kokil, Ganesh R.
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Boyd, Robert
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show more...
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Hu, Zhang-Jun
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Dang, Tram T.
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Persson, Per O A
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Uvdal, Kajsa
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Inorganic Chemis ...
- Articles in the publication
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ACS Omega
- By the university
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Linköping University