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Parental TB associa...
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Lopez-Cervantes, J. P.Univ Bergen, Norway; Haukeland Hosp, Norway
(author)
Parental TB associated with offspring asthma and rhinitis
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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Paris, France :International Union Against Tuberculosis and Lung Disease,2022
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LIBRIS-ID:oai:DiVA.org:liu-186839
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-186839URI
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https://doi.org/10.5588/ijtld.21.0603DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies: Research Council of Norway Toppforsk Programme, Oslo, Norway [274767]
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BACKGROUND: Infections in early life are associated with asthma and allergies in one-generation settings; however, the link between parental infection and offspring phenotype is rarely investigated. We aim to study the association of parental TB before conception of the offspring with offspring asthma and rhinitis.METHODS: We included 2,965 offspring born in 1985- 2004 and registered in the Norwegian prescription database to 1,790 parents born after 1960 with a history of TB, and included in the Norwegian TB registry. Offspring asthma (n = 582) and rhinitis (n = 929) were defined based on diagnosis, type of medication and prescribed medication >1 year. Associations of parental TB ,8 years, >8 years but before offsprings birth year and after birth (reference category) with offspring asthma and rhinitis were analysed using logistic regression.RESULTS: Asthma risk was higher in persons with parental TB in childhood (OR 1.73, 95% CI 1.20- 2.50) or later preconception (OR 1.38, 95% CI 1.00- 1.91) than in persons with parental TB after offsprings birth; this was significant only in the maternal line (childhood: OR 1.95, 95% CI 1.13-3.37; later precon-ception: OR 1.74, 95% CI 1.08-2.80). Associations with rhinitis were not identified.CONCLUSIONS: Parental childhood TB was associated with higher asthma risk in future offspring. We speculate that TB impacts maternal immunity , dysregulates the offsprings type 2 immunity , that TB-induced epigenetic reprograming of immune defences are trans-ferred to the offspring.
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Shigdel, R.Univ Bergen, Norway
(author)
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Accordini, S.Univ Verona, Italy
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Mustafa, T.Univ Bergen, Norway
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Bertelsen, R. J.Univ Bergen, Norway
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Makvandi-Nejad, S.Univ Bergen, Norway; Haukeland Hosp, Norway
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Lerm, Maria,Professor,1973-Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)marle69
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Horsnell, W.Univ Cape Town, South Africa; Univ Birmingham, England
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Svanes, C.Univ Bergen, Norway; Haukeland Hosp, Norway
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Univ Bergen, Norway; Haukeland Hosp, NorwayUniv Bergen, Norway
(creator_code:org_t)
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In:The International Journal of Tuberculosis and Lung DiseaseParis, France : International Union Against Tuberculosis and Lung Disease26:6, s. 544-5491027-37191815-7920
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Shigdel, R.
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Accordini, S.
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Mustafa, T.
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Bertelsen, R. J.
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Makvandi-Nejad, ...
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Lerm, Maria, Pro ...
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Horsnell, W.
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Linköping University