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Scene memory and hippocampal volume in middle-aged women with early hormone loss

Gervais, Nicole J. (author)
Univ Toronto, Canada; Rotman Res Inst, Canada
Gravelsins, Laura (author)
Univ Toronto, Canada
Brown, Alana (author)
Univ Toronto, Canada
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Reuben, Rebekah (author)
Univ Toronto, Canada
Karkaby, Laurice (author)
Univ Toronto, Canada
Baker-Sullivan, Elizabeth (author)
Univ Toronto, Canada
Mendoza, Leanne (author)
Univ Toronto, Canada
Lauzon, Claire (author)
Univ Toronto, Canada
Almey, Anne (author)
Univ Toronto, Canada; McGill Univ, Canada
Foulkes, William D. (author)
McGill Univ, Canada; Jewish Gen Hosp, Canada
Bernardini, Marcus Q. (author)
Univ Hlth Network, Canada
Jacobson, Michelle (author)
Univ Hlth Network, Canada
Velsher, Lea (author)
North York Gen Hosp, Canada
Rajah, M. Natasha (author)
McGill Univ, Canada
Olsen, Rosanna K. (author)
Univ Toronto, Canada; Rotman Res Inst, Canada
Grady, Cheryl (author)
Univ Toronto, Canada; Rotman Res Inst, Canada; Univ Toronto, Canada
Einstein, Gillian (author)
Linköpings universitet,Tema Genus,Filosofiska fakulteten,Univ Toronto, Canada; Rotman Res Inst, Canada; Womens Coll Res Inst, Canada
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 (creator_code:org_t)
ELSEVIER SCIENCE INC, 2022
2022
English.
In: Neurobiology of Aging. - : ELSEVIER SCIENCE INC. - 0197-4580 .- 1558-1497. ; 117, s. 97-106
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The present study explored whether early midlife bilateral salpingo-oophorectomy (BSO), a female specific risk factor for dementia, is associated with reduced medial temporal lobe structure and function. Younger middle-aged women with the BRCA1/2 mutation and a BSO prior to spontaneous menopause (SM) were recruited. We determined the performance of women with BSO not taking estradiol-based hormone therapy ( n = 18) on a task measuring object and scene recognition and quantified medial temporal lobe subregion volumes using manually segmented high-resolution T2-weighted MRI scans. Comparisons were made to those with BSO taking estradiol-based hormone therapy ( n = 20), age-matched premenopausal controls ( n = 28), and older women in SM not taking hormone therapy matched for duration of hormone deprivation ( n = 17). Reduced hippocampal integrity specific to the BSO group not taking hormone therapy was observed, reflected by significantly smaller dentate gyrus/CA2/CA3 volumes and lower scene recognition memory performance. These findings show that hippocampal subfield volume may be useful for identifying early midlife changes in women at elevated risk for dementia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)

Keyword

Bilateral oophorectomy; Estradiol; Memory; Neuroimaging; Hippocampus; Scene recognition memory

Publication and Content Type

ref (subject category)
art (subject category)

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