SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:liu-187514"
 

Search: onr:"swepub:oai:DiVA.org:liu-187514" > Adverse events duri...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Eriksson, VictoriaUmeå universitet,Urologi och andrologi,Umea Univ, Sweden (author)

Adverse events during neoadjuvant chemotherapy for muscle invasive bladder cancer - a Swedish retrospective multicentre study of a clinical database

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-08
  • AME Publishing Company,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-187514
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187514URI
  • https://doi.org/10.21037/tau-22-78DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199325URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council [Bas-ALF/VLL RV-848051]; Cancer Research Foundation in Norrland, Umea, Sweden [CFF LP 13-2000]
  • Background: Adverse events (AEs) during neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer (MIBC) are known but insufficiently reported. Clinical implications include affected cardiac, pulmonary, urinary, vascular and haematological organ systems. The main purpose was to evaluate the incidence and severity of AEs for ascertaining possible clinical significance. Further investigating possible effects of AEs on downstaging outcomes-downstaging is considered a surrogate marker for overall survival (OS).Methods: A retrospective evaluation of AEs during ongoing NAC for MIBC patients analysing individual patient data in a clinical database. We identified 687 cystectomies between 2009-2020 at four Swedish urological centres. Inclusion criteria were cT2-4aN0M0 in 261 NAC patients undergoing radical cystectomy (RC). Medical files were reviewed and AEs were assessed and graded, including detailed measurements by the Common Terminology Criteria for Adverse Events (CTCAE) v.5. Data were retrospectively analysed in SPSS statistics 27.0 with Spearman rank-order correlation coefficient and Mann-Whitney U-test (MWU).Results: A total of 251/261 patients [95% confidence interval (CI), 93-98%] experienced AEs during NAC pre-RC (mean two AEs/patient). In total, 208 (80%) patients received methotrexate, vinblastine, adriamycin (doxorubicin) and cisplatin (MVAC). In the total cohort, 200 (76.6%) received all pre-planned NAC-cycles. Most common AEs were anaemia (88.9%), thrombocytopenia (44.8%) and acute kidney injury (40.6%). Patients with prematurely terminated cycles had higher AE-grades (P=0.042 MWU). A correlation between higher AE-grades and decrease in downstaging existed, in the entire cohort (-0.133; P=0.033) and in patients undergoing all pre-planned NAC-cycles (-0.148; P=0.038). Anaemia and acute kidney injury were individually associated with decreased downstaging (-0.360, P=0.025 and -0.183, P=0.010, respectively).Conclusion: NAC in MIBC poses a significant risk for AEs before RC with clinical implications. For instance, patients terminating chemotherapy prematurely, have higher AE-grades and decreased downstaging. Further, acute kidney injury and anaemia are individually associated with decreased downstaging. We propose that early detection and prevention of AEs may increase downstaging of the primary tumour.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Holmlund, JennieUmeå universitet,Urologi och andrologi,Umea Univ, Sweden (author)
  • Wiberg, ErikUmeå universitet,Urologi och andrologi,Umea Univ, Sweden(Swepub:umu)erwi0035 (author)
  • Johansson, MarkusUmeå universitet,Urologi och andrologi,Umea Univ, Sweden (author)
  • Huge, YlvaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland,Department of Clinical and Experimental Medicine, Division of Urology, Linköping University, Linköping, Sweden(Swepub:liu)ylvhu61 (author)
  • Alamdari, FarhoodVastmanland Hosp, Sweden,Department of Urology, Västmanland Hospital, Västerås, Sweden (author)
  • Svensson, Johan,1978-Umeå universitet,Statistik,Umea Univ, Sweden(Swepub:umu)josv0027 (author)
  • Aljabery, FirasLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland,Department of Clinical and Experimental Medicine, Division of Urology, Linköping University, Linköping, Sweden(Swepub:liu)firab05 (author)
  • Sherif, AmirUmeå universitet,Urologi och andrologi,Umea Univ, Sweden; Umea Univ, Sweden(Swepub:umu)amsh0008 (author)
  • Umeå universitetUrologi och andrologi (creator_code:org_t)

Related titles

  • In:Translational Andrology and Urology: AME Publishing Company11:8, s. 1105-11152223-46832223-4691

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view