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Comparison of Effic...
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Tikkanen, M.J.Helsinki University Central Hospital
(author)
Comparison of Efficacy and Safety of Atorvastatin (80 mg) to Simvastatin (20 to 40 mg) in Patients Aged less than65 Versus =65 Years With Coronary Heart Disease (from the Incremental DEcrease through Aggressive Lipid Lowering [IDEAL] Study)
- Article/chapterEnglish2009
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Elsevier BV,2009
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LIBRIS-ID:oai:DiVA.org:liu-18830
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18830URI
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https://doi.org/10.1016/j.amjcard.2008.10.029DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The efficacy and safety of atorvastatin (80 mg/day) versus simvastatin (20 to 40 mg/day) in older (age =65 years) versus younger (less than65 years) patients were assessed in a prespecified secondary analysis of the 8,888 patients with myocardial infarction in the IDEAL trial, a randomized open-label study. Several cardiovascular end points were evaluated, including the occurrence of a first major coronary event (MCE; nonfatal myocardial infarction, coronary heart disease death, or resuscitated cardiac arrest), the primary end point of the trial, and occurrence of any cardiovascular event (MCE, stroke, revascularization, unstable angina, congestive heart failure, and peripheral artery disease). Although there were no significant interactions between age and treatment, the magnitude of effect in favor of atorvastatin was higher in younger versus older patients (occurrence of first MCE, hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.66 to 0.98; and HR 0.95, 95% CI 0.80 to 1.15, respectively; occurrence of any cardiovascular (CV) event, HR 0.80, 95% CI 0.71 to 0.89; and HR 0.88, 95% CI 0.79 to 0.99, respectively). These results were likely influenced by adherence, which was lower in older patients and those receiving atorvastatin compared with those receiving simvastatin. Rates of any reported serious adverse event were higher in older patients, but did not differ between the 2 statin groups. In conclusion, except for any CV events in the older group, significant reductions in primary and secondary end points were observed only in patients less than65 years of age. The safety of atorvastatin (80 mg) and simvastatin (20 to 40 mg) was similar in patients aged less than65 and greater than65 years with stable coronary disease.
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Holme, I.Ullevål University Hospital
(author)
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Cater, N.B.Pfizer Inc
(author)
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Szarek, M.Pfizer Inc
(author)
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Faergeman, O.Århus University Hospital
(author)
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Kastelein, J.J.P.Academic Hospital Amsterdam
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Olsson, AndersÖstergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)andol21
(author)
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Larsen, M.L.Århus University Hospital
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Lindahl, C.Pfizer Sweden
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Pedersen, T.R.Ullevål University Hospital
(author)
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Helsinki University Central HospitalUllevål University Hospital
(creator_code:org_t)
Related titles
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In:American Journal of Cardiology: Elsevier BV103:5, s. 577-5820002-9149
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Tikkanen, M.J.
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Holme, I.
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Cater, N.B.
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Szarek, M.
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Faergeman, O.
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Kastelein, J.J.P ...
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Olsson, Anders
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Larsen, M.L.
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Lindahl, C.
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Pedersen, T.R.
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Linköping University