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  • Campbell, RachelUniv Sydney, Australia (author)

Measure of Ovarian Symptoms and Treatment concerns (MOST) indexes and their associations with health-related quality of life in recurrent ovarian cancer

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • ACADEMIC PRESS INC ELSEVIER SCIENCE,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-188450
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-188450URI
  • https://doi.org/10.1016/j.ygyno.2022.05.024DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150572939URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|NHMRC, Australia [1063012, 570893]; Target Ovarian Cancer [UCL-P001AL]; Cancer Research UK; UCL Cancer Trials Centre [C444/A15953]; NHMRC program [APP1092856]; Australian Government through Cancer Australia; NHMRC Program; Department of Health
  • Purpose. The Measure of Ovarian Symptoms and Treatment (MOST) concerns is a validated patient-reported symptom assessment tool for assessing symptom benefit and adverse effects of palliative chemotherapy in women with recurrent ovarian cancer (ROC). We aimed to examine (i) how symptoms within MOST symptom indexes track together (i.e. co-occur) and (ii) the association between MOST symptom indexes and key aspects of health-related quality of life (HRQL). Method. A prospective cohort of women with ROC completed the MOST-T35, EORTC QLQ-C30 and EORTC QLQ-OV28 at baseline and before each cycle of chemotherapy. Analyses were conducted on baseline and end -of-treatment data. Exploratory factor analysis and hierarchical cluster analysis identified groups of co-occurring symptoms. Path models examined associations between MOST symptom indexes and HRQL. Results. Data from 762 women at baseline and 681 at treatment-end who completed all 22 symptom-specific MOST items and at least one HRQL measure were analysed. Four symptom clusters emerged at baseline and treatment-end: abdominal symptoms, symptoms associated with peripheral neuropathy, nausea and vomiting, and psychological symptoms. Psychological symptoms (MOST-Psych) and symptoms due to disease (ovarian cancer) or treatment (MOST-DorT) were associated with poorer scores on QLQ-C30 and OV28 functioning do-mains and worse overall health at both time points. Conclusion. Four MOST symptom clusters were consistent across statistical methods and time points. These findings suggest that routine standardized assessment of psychological and physical symptoms in clinical prac-tice with MOST plus appropriate symptom management referral pathways is an intervention for improving HRQL that warrants further research. (c) 2022 Elsevier Inc. All rights reserved.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Costa, Daniel S. J.Univ Sydney, Australia,Arbeitsgesmeinschaft Gynakol Onkol Studiengrp AGO, Germany; North Eastern German Soc Gynecol Oncol NOGGO, Germany; Charite, Germany (author)
  • Stockler, Martin R.Univ Sydney, Australia (author)
  • Lee, Yeh ChenUniv Sydney, Australia; Australia New Zealand Gynaecol Oncol Grp ANZGOG, Australia; Prince Wales Hosp, Australia (author)
  • Ledermann, Jonathan A.NCRI UK, England (author)
  • Berton, DominiqueGINECO Grp Invest Nationaux Etud Canc Ovariens, France; Ctr Rene Gauducheau, France (author)
  • Sehouli, JalidArbeitsgesmeinschaft Gynakol Onkol Studiengrp AGO, Germany; North Eastern German Soc Gynecol Oncol NOGGO, Germany; Charite, Germany (author)
  • Roncolato, Felicia T.Univ Sydney, Australia; Australia New Zealand Gynaecol Oncol Grp ANZGOG, Australia; Prince Wales Hosp, Australia; Campbelltown Hosp, Australia (author)
  • Connell, Rachel O.Univ Sydney, Australia (author)
  • Okamoto, AikouJapanese Gynecol Oncol Grp JGOG, Japan; Jikei Univ, Japan (author)
  • Bryce, JaneIst Nazl Tumori IRCCS, Italy; Ascens St John Clin Res Inst, OK USA (author)
  • Oza, Amit M.Princess Margaret Consortium PMHC, Canada; Univ Toronto, Canada (author)
  • Åvall Lundqvist, ElisabethLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Nordic Soc Gynaecol Oncol NSGO, Denmark; Karolinska Inst, Sweden(Swepub:liu)eliav51 (author)
  • Berek, Jonathan S.Cooperat Gynecol Oncol Investigators COGI, CA USA; Stanford Univ, CA USA (author)
  • Lanceley, AnneUCL, England (author)
  • Joly, FlorenceGINECO Grp Invest Nationaux Etud Canc Ovariens, France; Ctr Francois Baclesse, France (author)
  • Hilpert, FelixArbeitsgesmeinschaft Gynakol Onkol Studiengrp AGO, Germany; North Eastern German Soc Gynecol Oncol NOGGO, Germany; Krankenhaus Jerusalem, Germany (author)
  • Feeney, AmandaNCRI UK, England (author)
  • Kaminsky, Marie C.GINECO Grp Invest Nationaux Etud Canc Ovariens, France; Alexis Vautrin, France (author)
  • Diamante, KatrinaUniv Sydney, Australia (author)
  • Friedlander, Michael L.Australia New Zealand Gynaecol Oncol Grp ANZGOG, Australia; Prince Wales Hosp, Australia (author)
  • King, Madeleine T.Univ Sydney, Australia (author)
  • Univ Sydney, AustraliaArbeitsgesmeinschaft Gynakol Onkol Studiengrp AGO, Germany; North Eastern German Soc Gynecol Oncol NOGGO, Germany; Charite, Germany (creator_code:org_t)

Related titles

  • In:Gynecologic Oncology: ACADEMIC PRESS INC ELSEVIER SCIENCE166:2, s. 254-2620090-82581095-6859

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