Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial

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Hande, Liv NesseNordland Hosp, Norway; UiT Arctic Univ Norway, Norway (author)

Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia : A Randomized Crossover Trial

Article/chapterEnglish2022

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2022-07-27
MDPI,2022
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LIBRIS-ID:oai:DiVA.org:liu-188452
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-188452URI
https://doi.org/10.3390/biomedicines10081809DOI

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Language:English
Summary in:English

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Funding Agencies|Northern Norway Regional Health Authority (Helse Nord RHF) [SFP1311-16]; UiT The Arctic University of Norway
Individuals with familial hypercholesterolemia (FH) have an increased risk of cardiovascular disease. Treatment is mainly low-density lipoprotein cholesterol (LDL-C) reduction. How omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplements affect lipoproteins in FH subjects is unknown. We hypothesized that a high-dose n-3 PUFA supplement would reduce atherogenic lipoproteins and influence the high-density lipoprotein cholesterol (HDL-C) function. We performed a randomized, double-blinded crossover study with 34 genetically verified FH individuals (18-75 years, clinically stable, statin treatment > 12 months). Treatment was 4 g n-3 PUFAs (1840 mg eicosapentaenoic acid and 1520 mg docosahexaenoic acid daily) or four capsules of olive oil for three months in a crossover design with a washout period of three months. The defined outcomes were changes in triglycerides, lipoproteins, lipoprotein subfractions, apolipoproteins, and HDL-C function. After treatment with n-3 PUFAs, total cholesterol, LDL-C, and triglycerides were reduced compared to placebo (p <= 0.01 for all). Total HDL-C levels were unchanged, but the subfraction of large HDL-C was higher (p <= 0.0001) after n-3 PUFAs than after placebo, and intermediate HDL-C and small HDL-C were reduced after n-3 PUFAs compared to placebo (p = 0.02 and p <= 0.001, respectively). No changes were found in apolipoproteins and HDL-C function. N-3 PUFAs supplements reduced atherogenic lipoproteins in FH subjects, leaving HDL-C function unaffected.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
familial hypercholesterolemia; omega-3 fatty acids; lipids; cardiovascular disease; randomized trial

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Kjellmo, ChristianNordland Hosp, Norway; UiT Arctic Univ Norway, Norway (author)
Pettersen, KristinNordland Hosp, Norway (author)
Ljunggren, StefanLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin(Swepub:liu)stelj68 (author)
Karlsson, HelenLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin(Swepub:liu)helka90 (author)
Cederbrant, KarinLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)karce90 (author)
Marcusson-Ståhl, MarithaSwedish Toxicol Sci Res Ctr, Sweden (author)
Hovland, AndersNordland Hosp, Norway; UiT Arctic Univ Norway, Norway (author)
Lappegard, Knut ToreNordland Hosp, Norway; UiT Arctic Univ Norway, Norway (author)
Nordland Hosp, Norway; UiT Arctic Univ Norway, NorwayNordland Hosp, Norway (creator_code:org_t)

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In:Biomedicines: MDPI10:82227-9059

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