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NET Formation in Sy...
NET Formation in Systemic Lupus Erythematosus : Changes during the COVID-19 Pandemic
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- Knopf, Jasmin (author)
- Friedrich Alexander Univ Erlangen Nurnberg FAU, Germany; Univ Klinikum Erlangen, Germany; Friedrich Alexander Univ Erlangen Nurnberg FAU, Germany
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- Sjöwall, Johanna (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland
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- Frodlund, Martina (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Hinkula, Jorma (author)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Herrmann, Martin (author)
- Friedrich Alexander Univ Erlangen Nurnberg FAU, Germany; Univ Klinikum Erlangen, Germany; Friedrich Alexander Univ Erlangen Nurnberg FAU, Germany
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- Sjöwall, Christopher (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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(creator_code:org_t)
- 2022-08-23
- 2022
- English.
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In: Cells. - : MDPI. - 2073-4409. ; 11:17
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- The severity of the coronavirus disease in 2019 (COVID-19) is strongly linked to a dysregulated immune response. This fuels the fear of severe disease in patients with autoimmune disorders continuously using immunosuppressive/immunomodulating medications. One complication of COVID-19 is thromboembolism caused by intravascular aggregates of neutrophil extracellular traps (NETs) occluding the affected vessels. Like COVID-19, systemic lupus erythematosus (SLE) is characterized by, amongst others, an increased risk of thromboembolism. An imbalance between NET formation and clearance is suggested to play a prominent role in exacerbating autoimmunity and disease severity. Serologic evidence of exposure to SARS-CoV-2 has a minor impact on the SLE course in a Swedish cohort reportedly. Herein, we assessed NET formation in patients from this cohort by neutrophil elastase (NE) activity and the presence of cell-free DNA, MPO-DNA, and NE-DNA complexes and correlated the findings to the clinical parameters. The presence of NE-DNA complexes and NE activity differed significantly in pre-pandemic versus pandemic serum samples. The latter correlated significantly with the hemoglobin concentration, blood cell counts, and complement protein 3 and 4 levels in the pre-pandemic but only with the leukocyte count and neutrophil levels in the pandemic serum samples. Taken together, our data suggest a change, especially in the NE activity independent of exposure to SARS-CoV-2.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- COVID-19; SARS-CoV-2; systemic lupus erythematosus (SLE); neutrophils; neutrophil extracellular traps (NETs)
Publication and Content Type
- ref (subject category)
- art (subject category)
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