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Defining post-acute...
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells
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- Nikesjö, Frida (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Lungmedicinska kliniken US
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- Sayyab, Shumaila (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Karlsson, Lovisa (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Apostolou, Eirini, 1977- (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Rosén, Anders, 1948- (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Hedman, Kristofer, Docent, 1984- (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US
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- Lerm, Maria, Professor, 1973- (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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(creator_code:org_t)
- Research Square Platform LLC, 2022
- English.
- Related links:
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
Close
- Post-Acute COVID-19 Syndrome (PACS) has been defined as symptoms persisting after clearance of a COVID-19 infection. We have previously demonstrated that alterations in DNA methylation (DNAm) status persists in individuals who recovered from a COVID-19 infection, but it is currently unknown if PACS is associated with epigenetic changes. We compared DNAm patterns in patients with PACS with those in controls and in healthy COVID-19 convalescents and found a unique DNAm signature in PACS patients. This signature unravelled modified pathways that regulate angiotensin II and muscarinic receptor signalling and protein-protein interaction networks that have bearings on vesicle formation and mitochondrial function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Post-Acute COVID-19 Syndrome
- PACS
- COVID-19
- SARS-CoV-2
- PBMC
- epigenetics
- DNA methylation
- biosignature
Publication and Content Type
- vet (subject category)
- ovr (subject category)
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