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  • Gerdin, LindaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Surg Clin Jonkoping Cty, Sweden (author)

Acute psychological stress increases paracellular permeability and modulates immune activity in rectal mucosa of healthy volunteers

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2022-10-31
  • John Wiley & Sons Ltd,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-189926
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189926URI
  • https://doi.org/10.1002/ueg2.12329DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Fondo de Investigacion Sanitaria and CIBERehd, Instituto de Salud Carlos III, Subdireccion General de Investigacion Sanitaria, Ministerio de Economia y Competitividad [PI17/0190, PI19/01643]; Futurum, Region Jonkoping County [12406, 1460]; Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas [CB06/04/0021]; Vetenskapsradet [2014-02537, 2017-02475]; Forskningsradet i Sydostra Sverige [37841]
  • Background Psychological stress and increased permeability are implicated as contributing factors in the initiation and worsening of gastrointestinal diseases. A link between stress and intestinal permeability has been shown in animal models as well as in human small intestine, but stress effects on the human colorectal mucosal barrier has not been reported. Objective To investigate the potential effects of acute psychological stress on colorectal mucosal barrier function and to explore stress-induced molecular events in the rectal mucosa under healthy conditions. Methods Endoscopic biopsies were taken from the rectosigmoid region of healthy volunteers, who had been subjected to dichotomous listening stress and after a control session, respectively. Paracellular and transcellular permeability were assessed in modified Ussing chambers. RNA expression (microarray technology confirmed by quantitative real-time polymerase chain reaction) and biological pathway analysis were used to investigate the local mucosal response to acute stress. Results Dichotomous listening stress induced a subjective and objective stress response, and significantly increased paracellular but not transcellular permeability. We also identified a stress-induced reduction in RNA expression of genes related to immune cell activation and maturation (CR2, CD20, TCLA1, BANK1, CD22, FDCSP), signaling molecules of homing of immune cells to the gut (chemokines: CCL21, CXCL13, and CCL19, and receptors: CCR7, CXCR5), and innate immunity (DUOX2). Eight of the 10 top down-regulated genes are directly involved in B cell activation, signaling and migration. The systemic stress response correlated positively with paracellular permeability and negatively with DUOX2 expression. Conclusion Dichotomous listening stress increases paracellular permeability and modulates immune cell activity in the rectal mucosa. Further studies are warranted to identify the primary mechanisms of stress-mediated reduction of mucosal defensive activity and barrier dysfunction, and their potential implications for gastrointestinal disorders.

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  • Gonzalez-Castro, Ana M.Univ Autonoma Barcelona, Spain; Univ Autonoma Barcelona, Spain (author)
  • Ericson, Ann-CharlottLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)anner00 (author)
  • Persborn, MatsSurg Clin Jonkoping Cty, Sweden (author)
  • Santos, JavierUniv Autonoma Barcelona, Spain; Univ Autonoma Barcelona, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain (author)
  • Walter, SusannaLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)suswa35 (author)
  • Keita, ÅsaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)asave24 (author)
  • Vicario, MariaUniv Autonoma Barcelona, Spain; Univ Autonoma Barcelona, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain; Nestle Res Soc Prod Nestle SA, Switzerland (author)
  • Söderholm, Johan DLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)sodda63 (author)
  • Linköpings universitetAvdelningen för kirurgi, ortopedi och onkologi (creator_code:org_t)

Related titles

  • In:United European Gastroenterology journal: John Wiley & Sons Ltd11:1, s. 31-412050-64062050-6414

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