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First Episodes of N...
First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort
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- Vielot, Nadja A. (author)
- Department of Family Medicine, University of North Carolina, Chapel Hill, NC
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- Reyes, Yaoska (author)
- Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua-León, León, Nicaragua
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- Blette, Bryan (author)
- Department of Biostatistics, University of North Carolina, Chapel Hill, NC
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- González, Fredman (author)
- Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua-León, León, Nicaragua
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- Toval-Ruiz, Christian (author)
- Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua-León, León, Nicaragua
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- Gutiérrez, Lester (author)
- Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua-León, León, Nicaragua
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- Vilchez, Samuel (author)
- Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua-León, León, Nicaragua
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- Diez-Valcarce, Marta (author)
- Division of Viral Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, GA; Emory University, Rollins School of Public Health, Atlanta, GA
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- Vinjé, Jan (author)
- Division of Viral Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, GA
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- Becker-Dreps, Sylvia (author)
- Department of Family Medicine, University of North Carolina, Chapel Hill, NC; Department of Epidemiology, University of North Carolina, Chapel Hill, NC.
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- Bucardo, Filemón (author)
- Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua-León, León, Nicaragua
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(creator_code:org_t)
- 2022
- 2022
- English.
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In: Epidemiology. - 1044-3983 .- 1531-5487. ; 33:5, s. 650-653
- Related links:
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https://journals.lww...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Norovirus and sapovirus cause a large burden of acute gastroenteritis (AGE) in young children. We assessed protection conferred by norovirus and sapovirus AGE episodes against future episodes.Methods: Between June 2017 and July 2018, we recruited 444 newborns in León, Nicaragua. Weekly household surveys identified AGE episodes over 36 months, and AGE stools were tested by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) for norovirus genogroup (G)I/GII and sapovirus. We used recurrent-event Cox models and negative control methods to estimate protection conferred by first episodes, controlling for observed and unobserved risk factors, respectively.Results: Sapovirus episodes conferred a 69% reduced hazard of subsequent episodes using the negative control method. Norovirus GI (hazard ratio [HR] = 0.67; 95% confidence interval [CI] = 0.31, 1.3) and GII (HR = 0.20; 95% CI = 0.04, 0.44) episodes also appeared highly protective. Protection against norovirus GII was enhanced following two episodes.Conclusions: Evidence of natural immunity in early childhood provides optimism for the future success of pediatric norovirus and sapovirus vaccines.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Children
- Diarrhea
- Gastroenteritis
- Nicaragua
- Norovirus
- Sapovirus
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vielot, Nadja A.
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Reyes, Yaoska
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Blette, Bryan
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González, Fredma ...
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Toval-Ruiz, Chri ...
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Gutiérrez, Leste ...
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show more...
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Vilchez, Samuel
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Diez-Valcarce, M ...
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Vinjé, Jan
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Becker-Dreps, Sy ...
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Bucardo, Filemón
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Epidemiology
- By the university
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Linköping University