Search: onr:"swepub:oai:DiVA.org:liu-190234" >
Acute Myocarditis A...
Acute Myocarditis Associated With Desmosomal Gene Variants
-
- Ammirati, Enrico (author)
- Osped Niguarda Ca Granda, Italy; Osped Niguarda Ca Granda, Italy
-
- Raimondi, Francesca (author)
- M3C Hop Necker Enfants Malad, France
-
- Piriou, Nicolas (author)
- Univ Nantes, France
-
show more...
-
- Infirri, Loren Sardo (author)
- Osped Circolo Varese, Italy
-
- Mohiddin, Saidi A. (author)
- St Bartholomews Hosp, England
-
- Mazzanti, Andrea (author)
- IRCCS, Italy; Univ Pavia, Italy
-
- Shenoy, Chetan (author)
- Univ Minnesota, MN USA
-
- Cavallari, Ugo A. (author)
- Osped Niguarda Ca Granda, Italy
-
- Imazio, Massimo (author)
- Cardiothorac Dept, Italy
-
- Aquaro, Giovanni Donato (author)
- Gabriele Monasterio Fdn, Italy
-
- Olivotto, Iacopo (author)
- Careggi Univ Hosp, Italy
-
- Pedrotti, Patrizia (author)
- Osped Niguarda Ca Granda, Italy
-
- Sekhri, Neha (author)
- St Bartholomews Hosp, England
-
- Heyning, Caroline M. Van de (author)
- Antwerp Univ Hosp, Belgium
-
- Broeckx, Glenn (author)
- Antwerp Univ Hosp, Belgium
-
- Peretto, Giovanni (author)
- Univ Vita Salute San Raffaele, Italy
-
- Guttmann, Oliver (author)
- St Bartholomews Hosp, England
-
- Dellegrottaglie, Santo (author)
- Clin Villa Fiori, Italy
-
- Scatteia, Alessandra (author)
- Clin Villa Fiori, Italy
-
- Gentile, Piero (author)
- Osped Niguarda Ca Granda, Italy
-
- Merlo, Marco (author)
- Univ Trieste, Italy
-
- Goldberg, Randal I. (author)
- NYU Langone Hlth, NY USA
-
- Reyentovich, Alex (author)
- NYU Langone Hlth, NY USA
-
- Sciamanna, Christopher (author)
- Univ Illinois, IL USA
-
- Klaassen, Sabine (author)
- Corp Member Freie Universitdt Berlin & Humboldt Un, Germany; Expt & Clin Res Ctr, Germany
-
- Poller, Wolfgang (author)
- Corp Member Freie Universitdt Berlin & Humboldt Un, Germany; German Ctr Cardiovasc Res, Germany; Dept Cardiol, Germany
-
- Trankle, Cory R. (author)
- Virginia Commonwealth Univ, VA USA
-
- Abbate, Antonio (author)
- Virginia Commonwealth Univ, VA USA
-
- Keren, Andre (author)
- Hadassah Hebrew Univ Med Ctr, Israel
-
- Horowitz-Cederboim, Smadar (author)
- Hadassah Ctr Cardiogenet, Israel
-
- Cadrin-Tourigny, Julia (author)
- Univ Montreal, Canada
-
- Tadros, Rafik (author)
- Univ Montreal, Canada
-
- Annoni, Giuseppe A. (author)
- Osped Niguarda Ca Granda, Italy
-
- Bonoldi, Emanuela (author)
- Osped Niguarda Ca Granda, Italy
-
- Toquet, Claire (author)
- Univ Nantes, France; Nantes Univ, France
-
- Marteau, Lara (author)
- Univ Nantes, France
-
- Probst, Vincent (author)
- Univ Nantes, France
-
- Trochu, Jean Noel (author)
- Univ Nantes, France
-
- Kissopoulou, Antheia (author)
- Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten
-
- Grosu, Aurelia (author)
- Cardiovasc Dept, Italy
-
- Kukavica, Deni (author)
- IRCCS, Italy; Univ Pavia, Italy
-
- Trancuccio, Alessandro (author)
- IRCCS, Italy; Univ Pavia, Italy
-
- Gil, Cristina (author)
- Univ Hosp Virgen Arrixaca, Spain; Univ Genoa, Italy
-
- Pedrazzini, Matteo (author)
- IRCCS Ist Auxol Italiano, Italy
-
- Torchio, Margherita (author)
- IRCCS Ist Auxol Italiano, Italy
-
- Sinagra, Gianfranco (author)
- Univ Trieste, Italy
-
- Gimeno, Juan Ramon (author)
- Univ Hosp Virgen Arrixaca, Spain
-
- Bernasconi, Davide (author)
- Univ Milano Bicocca, Italy
-
- Valsecchi, Maria Grazia (author)
- Univ Milano Bicocca, Italy
-
- Klingel, Karin (author)
- Univ Hosp Tubingen, Germany
-
- Adler, Eric D. (author)
- Univ Calif San Diego, CA USA
-
- Camici, Paolo G. (author)
- Univ Vita Salute San Raffaele, Italy
-
- Cooper, Leslie T. (author)
- Mayo Clin, FL USA; Mayo Clin Florida, FL 32224 USA
-
show less...
-
(creator_code:org_t)
- ELSEVIER SCI LTD, 2022
- 2022
- English.
-
In: JACC. Heart failure. - : ELSEVIER SCI LTD. - 2213-1779 .- 2213-1787. ; 10:10, s. 714-727
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND The risk of adverse cardiovascular events in patients with acute myocarditis (AM) and desmosomal gene variants (DGV) remains unknown.OBJECTIVES The purpose of this study was to ascertain the risk of death, ventricular arrhythmias, recurrent myocarditis, and heart failure (main endpoint) in patients with AM and pathogenic or likely pathogenetic DGV.METHODS In a retrospective international study from 23 hospitals, 97 patients were included: 36 with AM and DGV (DGV[+]), 25 with AM and negative gene testing (DGV[-]), and 36 with AM without genetics testing. All patients had troponin elevation plus findings consistent with AM on histology or at cardiac magnetic resonance (CMR). In 86 patients, CMR changes in function and structure were re-assessed at follow-up.RESULTS In the DGV(+) AM group (88.9% DSP variants), median age was 24 years, 91.7% presented with chest pain, and median left ventricular ejection fraction (LVEF) was 56% on CMR (P = NS vs the other 2 groups). Kaplan-Meier curves demonstrated a higher risk of the main endpoint in DGV(+) AM compared with DGV(-) and without genetics testing patients (62.3% vs 17.5% vs 5.3% at 5 years, respectively; P < 0.0001), driven by myocarditis recurrence and ventricular arrhythmias. At follow-up CMR, a higher number of late gadolinium enhanced segments was found in DGV(+) AM. CONCLUSIONS Patients with AM and evidence of DGV have a higher incidence of adverse cardiovascular events compared with patients with AM without DGV. Further prospective studies are needed to ascertain if genetic testing might improve risk stratification of patients with AM who are considered at low risk. (J Am Coll Cardiol HF 2022;10:714-727) (c) 2022 by the American College of Cardiology Foundation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiac magnetic resonance; desmoplakin; desmosomal gene variants; prognosis; acute myocarditis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ammirati, Enrico
-
Raimondi, France ...
-
Piriou, Nicolas
-
Infirri, Loren S ...
-
Mohiddin, Saidi ...
-
Mazzanti, Andrea
-
show more...
-
Shenoy, Chetan
-
Cavallari, Ugo A ...
-
Imazio, Massimo
-
Aquaro, Giovanni ...
-
Olivotto, Iacopo
-
Pedrotti, Patriz ...
-
Sekhri, Neha
-
Heyning, Carolin ...
-
Broeckx, Glenn
-
Peretto, Giovann ...
-
Guttmann, Oliver
-
Dellegrottaglie, ...
-
Scatteia, Alessa ...
-
Gentile, Piero
-
Merlo, Marco
-
Goldberg, Randal ...
-
Reyentovich, Ale ...
-
Sciamanna, Chris ...
-
Klaassen, Sabine
-
Poller, Wolfgang
-
Trankle, Cory R.
-
Abbate, Antonio
-
Keren, Andre
-
Horowitz-Cederbo ...
-
Cadrin-Tourigny, ...
-
Tadros, Rafik
-
Annoni, Giuseppe ...
-
Bonoldi, Emanuel ...
-
Toquet, Claire
-
Marteau, Lara
-
Probst, Vincent
-
Trochu, Jean Noe ...
-
Kissopoulou, Ant ...
-
Grosu, Aurelia
-
Kukavica, Deni
-
Trancuccio, Ales ...
-
Gil, Cristina
-
Pedrazzini, Matt ...
-
Torchio, Margher ...
-
Sinagra, Gianfra ...
-
Gimeno, Juan Ram ...
-
Bernasconi, Davi ...
-
Valsecchi, Maria ...
-
Klingel, Karin
-
Adler, Eric D.
-
Camici, Paolo G.
-
Cooper, Leslie T ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
JACC. Heart fail ...
- By the university
-
Linköping University