Search: onr:"swepub:oai:DiVA.org:liu-190234" > Acute Myocarditis A...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07088naa a2200925 4500 | |
001 | oai:DiVA.org:liu-190234 | |
003 | SwePub | |
008 | 221130s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1902342 URI |
024 | 7 | a https://doi.org/10.1016/j.jchf.2022.06.0132 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ammirati, Enricou Osped Niguarda Ca Granda, Italy; Osped Niguarda Ca Granda, Italy4 aut |
245 | 1 0 | a Acute Myocarditis Associated With Desmosomal Gene Variants |
264 | 1 | b ELSEVIER SCI LTD,c 2022 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|Italian Ministry of Health [GR-2019-12368506] | |
520 | a BACKGROUND The risk of adverse cardiovascular events in patients with acute myocarditis (AM) and desmosomal gene variants (DGV) remains unknown.OBJECTIVES The purpose of this study was to ascertain the risk of death, ventricular arrhythmias, recurrent myocarditis, and heart failure (main endpoint) in patients with AM and pathogenic or likely pathogenetic DGV.METHODS In a retrospective international study from 23 hospitals, 97 patients were included: 36 with AM and DGV (DGV[+]), 25 with AM and negative gene testing (DGV[-]), and 36 with AM without genetics testing. All patients had troponin elevation plus findings consistent with AM on histology or at cardiac magnetic resonance (CMR). In 86 patients, CMR changes in function and structure were re-assessed at follow-up.RESULTS In the DGV(+) AM group (88.9% DSP variants), median age was 24 years, 91.7% presented with chest pain, and median left ventricular ejection fraction (LVEF) was 56% on CMR (P = NS vs the other 2 groups). Kaplan-Meier curves demonstrated a higher risk of the main endpoint in DGV(+) AM compared with DGV(-) and without genetics testing patients (62.3% vs 17.5% vs 5.3% at 5 years, respectively; P < 0.0001), driven by myocarditis recurrence and ventricular arrhythmias. At follow-up CMR, a higher number of late gadolinium enhanced segments was found in DGV(+) AM. CONCLUSIONS Patients with AM and evidence of DGV have a higher incidence of adverse cardiovascular events compared with patients with AM without DGV. Further prospective studies are needed to ascertain if genetic testing might improve risk stratification of patients with AM who are considered at low risk. (J Am Coll Cardiol HF 2022;10:714-727) (c) 2022 by the American College of Cardiology Foundation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a cardiac magnetic resonance; desmoplakin; desmosomal gene variants; prognosis; acute myocarditis | |
700 | 1 | a Raimondi, Francescau M3C Hop Necker Enfants Malad, France4 aut |
700 | 1 | a Piriou, Nicolasu Univ Nantes, France4 aut |
700 | 1 | a Infirri, Loren Sardou Osped Circolo Varese, Italy4 aut |
700 | 1 | a Mohiddin, Saidi A.u St Bartholomews Hosp, England4 aut |
700 | 1 | a Mazzanti, Andreau IRCCS, Italy; Univ Pavia, Italy4 aut |
700 | 1 | a Shenoy, Chetanu Univ Minnesota, MN USA4 aut |
700 | 1 | a Cavallari, Ugo A.u Osped Niguarda Ca Granda, Italy4 aut |
700 | 1 | a Imazio, Massimou Cardiothorac Dept, Italy4 aut |
700 | 1 | a Aquaro, Giovanni Donatou Gabriele Monasterio Fdn, Italy4 aut |
700 | 1 | a Olivotto, Iacopou Careggi Univ Hosp, Italy4 aut |
700 | 1 | a Pedrotti, Patriziau Osped Niguarda Ca Granda, Italy4 aut |
700 | 1 | a Sekhri, Nehau St Bartholomews Hosp, England4 aut |
700 | 1 | a Heyning, Caroline M. Van deu Antwerp Univ Hosp, Belgium4 aut |
700 | 1 | a Broeckx, Glennu Antwerp Univ Hosp, Belgium4 aut |
700 | 1 | a Peretto, Giovanniu Univ Vita Salute San Raffaele, Italy4 aut |
700 | 1 | a Guttmann, Oliveru St Bartholomews Hosp, England4 aut |
700 | 1 | a Dellegrottaglie, Santou Clin Villa Fiori, Italy4 aut |
700 | 1 | a Scatteia, Alessandrau Clin Villa Fiori, Italy4 aut |
700 | 1 | a Gentile, Pierou Osped Niguarda Ca Granda, Italy4 aut |
700 | 1 | a Merlo, Marcou Univ Trieste, Italy4 aut |
700 | 1 | a Goldberg, Randal I.u NYU Langone Hlth, NY USA4 aut |
700 | 1 | a Reyentovich, Alexu NYU Langone Hlth, NY USA4 aut |
700 | 1 | a Sciamanna, Christopheru Univ Illinois, IL USA4 aut |
700 | 1 | a Klaassen, Sabineu Corp Member Freie Universitdt Berlin & Humboldt Un, Germany; Expt & Clin Res Ctr, Germany4 aut |
700 | 1 | a Poller, Wolfgangu Corp Member Freie Universitdt Berlin & Humboldt Un, Germany; German Ctr Cardiovasc Res, Germany; Dept Cardiol, Germany4 aut |
700 | 1 | a Trankle, Cory R.u Virginia Commonwealth Univ, VA USA4 aut |
700 | 1 | a Abbate, Antoniou Virginia Commonwealth Univ, VA USA4 aut |
700 | 1 | a Keren, Andreu Hadassah Hebrew Univ Med Ctr, Israel4 aut |
700 | 1 | a Horowitz-Cederboim, Smadaru Hadassah Ctr Cardiogenet, Israel4 aut |
700 | 1 | a Cadrin-Tourigny, Juliau Univ Montreal, Canada4 aut |
700 | 1 | a Tadros, Rafiku Univ Montreal, Canada4 aut |
700 | 1 | a Annoni, Giuseppe A.u Osped Niguarda Ca Granda, Italy4 aut |
700 | 1 | a Bonoldi, Emanuelau Osped Niguarda Ca Granda, Italy4 aut |
700 | 1 | a Toquet, Claireu Univ Nantes, France; Nantes Univ, France4 aut |
700 | 1 | a Marteau, Larau Univ Nantes, France4 aut |
700 | 1 | a Probst, Vincentu Univ Nantes, France4 aut |
700 | 1 | a Trochu, Jean Noelu Univ Nantes, France4 aut |
700 | 1 | a Kissopoulou, Antheiau Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten4 aut0 (Swepub:liu)n/a |
700 | 1 | a Grosu, Aureliau Cardiovasc Dept, Italy4 aut |
700 | 1 | a Kukavica, Deniu IRCCS, Italy; Univ Pavia, Italy4 aut |
700 | 1 | a Trancuccio, Alessandrou IRCCS, Italy; Univ Pavia, Italy4 aut |
700 | 1 | a Gil, Cristinau Univ Hosp Virgen Arrixaca, Spain; Univ Genoa, Italy4 aut |
700 | 1 | a Pedrazzini, Matteou IRCCS Ist Auxol Italiano, Italy4 aut |
700 | 1 | a Torchio, Margheritau IRCCS Ist Auxol Italiano, Italy4 aut |
700 | 1 | a Sinagra, Gianfrancou Univ Trieste, Italy4 aut |
700 | 1 | a Gimeno, Juan Ramonu Univ Hosp Virgen Arrixaca, Spain4 aut |
700 | 1 | a Bernasconi, Davideu Univ Milano Bicocca, Italy4 aut |
700 | 1 | a Valsecchi, Maria Graziau Univ Milano Bicocca, Italy4 aut |
700 | 1 | a Klingel, Karinu Univ Hosp Tubingen, Germany4 aut |
700 | 1 | a Adler, Eric D.u Univ Calif San Diego, CA USA4 aut |
700 | 1 | a Camici, Paolo G.u Univ Vita Salute San Raffaele, Italy4 aut |
700 | 1 | a Cooper, Leslie T.u Mayo Clin, FL USA; Mayo Clin Florida, FL 32224 USA4 aut |
710 | 2 | a Osped Niguarda Ca Granda, Italy; Osped Niguarda Ca Granda, Italyb M3C Hop Necker Enfants Malad, France4 org |
773 | 0 | t JACC. Heart failured : ELSEVIER SCI LTDg 10:10, s. 714-727q 10:10<714-727x 2213-1779x 2213-1787 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190234 |
856 | 4 8 | u https://doi.org/10.1016/j.jchf.2022.06.013 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Copy and save the link in order to return to this view