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Role of ventral sub...
Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier-induced voluntary abstinence
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- Fredriksson, Ida (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,NIDA, MD 21224 USA
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- Tsai, Pei-Jung (author)
- NIDA, MD USA
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- Shekara, Aniruddha (author)
- NIDA, MD 21224 USA
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- Duan, Ying (author)
- NIDA, MD USA
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- Applebey, Sarah V. (author)
- NIDA, MD 21224 USA
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- Minier-Toribio, Angelica (author)
- NIDA, MD 21224 USA
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- Batista, Ashley (author)
- NIDA, MD 21224 USA
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- Chow, Jonathan J. (author)
- NIDA, MD 21224 USA
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- Altidor, Lindsay (author)
- NIDA, MD 21224 USA
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- Barbier, Estelle (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Cifani, Carlo (author)
- Univ Camerino, Italy
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- Li, Xuan (author)
- Univ Maryland, MD 20742 USA
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- Reiner, David J. (author)
- NIDA, MD 21224 USA
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- Rubio, F. Javier (author)
- NIDA, MD 21224 USA
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- Hope, Bruce T. (author)
- NIDA, MD 21224 USA
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- Yang, Yihong (author)
- NIDA, MD USA
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- Bossert, Jennifer M. (author)
- NIDA, MD 21224 USA
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- Shaham, Yavin (author)
- NIDA, MD 21224 USA
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(creator_code:org_t)
- AMER ASSOC ADVANCEMENT SCIENCE, 2023
- 2023
- English.
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In: Science Advances. - : AMER ASSOC ADVANCEMENT SCIENCE. - 2375-2548. ; 9:2
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- High relapse rate is a key feature of opioid addiction. In humans, abstinence is often voluntary due to negative consequences of opioid seeking. To mimic this human condition, we recently introduced a rat model of incubation of oxycodone craving after electric barrier-induced voluntary abstinence. Incubation of drug craving refers to time-dependent increases in drug seeking after cessation of drug self-administration. Here, we used the activity marker Fos, muscimol-baclofen (GABAa + GABAb receptor agonists) global inactivation, Daun020-selective inactivation of putative relapse-associated neuronal ensembles, and fluorescence-activated cell sorting of Fos-positive cells and quantitative polymerase chain reaction to demonstrate a key role of vSub neuronal ensembles in incubation of oxycodone craving after voluntary abstinence, but not homecage forced abstinence. We also used a longitudinal functional magnetic resonance imaging method and showed that functional connectivity changes in vSub-related circuits predict opioid relapse after abstinence induced by adverse consequences of opioid seeking.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fredriksson, Ida
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Tsai, Pei-Jung
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Shekara, Anirudd ...
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Duan, Ying
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Applebey, Sarah ...
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Minier-Toribio, ...
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show more...
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Batista, Ashley
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Chow, Jonathan J ...
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Altidor, Lindsay
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Barbier, Estelle
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Cifani, Carlo
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Li, Xuan
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Reiner, David J.
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Rubio, F. Javier
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Hope, Bruce T.
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Yang, Yihong
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Bossert, Jennife ...
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Shaham, Yavin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Science Advances
- By the university
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Linköping University