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Tuberculosis-Associ...
Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome-An Extempore Game of Misfiring with Defense Arsenals
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- Vignesh, Ramachandran (author)
- Univ Kuala Lumpur, Malaysia
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- Balakrishnan, Pachamuthu (author)
- Saveetha Inst Med & Tech Sci SIMATS, India
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- Tan, Hong Yien (author)
- Xiamen Univ Malaysia, Malaysia
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- Yong, Yean Kong (author)
- Xiamen Univ Malaysia, Malaysia
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- Velu, Vijayakumar (author)
- Emory Univ, GA 30322 USA
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- Larsson, Marie (author)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Shankar, Esaki M. (author)
- Cent Univ Tamil Nadu, India
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(creator_code:org_t)
- 2023-01-29
- 2023
- English.
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In: Pathogens. - : MDPI. - 2076-0817. ; 12:2
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- The lethal combination involving TB and HIV, known as "syndemic" diseases, synergistically act upon one another to magnify the disease burden. Individuals on anti-retroviral therapy (ART) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS). The underlying inflammatory complication includes the rapid restoration of immune responses following ART, eventually leading to exaggerated inflammatory responses to MTB antigens. TB-IRIS continues to be a cause of morbidity and mortality among HIV/TB coinfected patients initiating ART, and although a significant quantum of knowledge has been acquired on the pathogenesis of IRIS, the underlying pathomechanisms and identification of a sensitive and specific diagnostic marker still remain a grey area of investigation. Here, we reviewed the latest research developments into IRIS immunopathogenesis, and outlined the modalities to prevent and manage strategies for better clinical and diagnostic outcomes for IRIS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- ART; biomarkers; HIV; inflammation; IRIS; tuberculosis
Publication and Content Type
- ref (subject category)
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