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Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila

Zhao, Yunpo (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Department of Molecular Biology, Umeå University, Umeå, Sweden; School of Medicine, University of Maryland, Baltimore, United States
Alenius, Mattias (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Max Planck Institute for Chemical Ecology, Jena, Germany; Department of Zoology and Entomology, Faculty of Science, Assiut University, Assiut, Egypt; Department of Neuroscience, Max Delbrück Center for Molecular Medicine, Berlin, D-13122, Germany,Department of Molecular Biology, Umeå University, Umeå, Sweden
Johansson, Emilia (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Department of Molecular Biology, Umeå University, Umeå, Sweden
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Dzaki, Najat (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Molecular Biology, Umeå University, Umeå, Sweden
Bhat, Shreelatha (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Department of Molecular Biology, Umeå University, Umeå, Sweden,Max Planck Institute for Chemical Ecology, Jena, Germany
Alfredsson, Johannes (author)
Gothenburg University,Göteborgs universitet,Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Department of Microbiology and Immunology, Gothenburg university, Gothenburg, Sweden,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Duan, Jianli (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Molecular Biology, Umeå University, Umeå, Sweden; School of Medicine, University of Maryland, Baltimore, United States
Hansson, B.S. (author)
Max Planck Institute for Chemical Ecology, Jena, Germany
Knaden, M. (author)
Max Planck Institute for Chemical Ecology, Jena, Germany
Alenius, M. (author)
Department of Molecular Biology, Umeå University, Umeå, Sweden
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 (creator_code:org_t)
2022-12-19
2022
English.
In: Nature Communications. - : Nature Research. - 2041-1723. ; 13:1
Related links:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Dietary composition affects food preference in animals. High sugar intake suppresses sweet sensation from insects to humans, but the molecular basis of this suppression is largely unknown. Here, we reveal that sugar intake in Drosophila induces the gut to express and secrete Hedgehog (Hh) into the circulation. We show that the midgut secreted Hh localize to taste sensilla and suppresses sweet sensation, perception, and preference. We further find that the midgut Hh inhibits Hh signalling in the sweet taste neurons. Our electrophysiology studies demonstrate that the midgut Hh signal also suppresses bitter taste and some odour responses, affecting overall food perception and preference. We further show that the level of sugar intake during a critical window early in life, sets the adult gut Hh expression and sugar perception. Our results together reveal a bottom-up feedback mechanism involving a “gut-taste neuron axis” that regulates food sensation and preference. © 2022, The Author(s).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

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