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Multi-organ single-...
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Lilja, SandraLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Mavatar Inc, Sweden
(author)
Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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ELSEVIER,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-193383
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-193383URI
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https://doi.org/10.1016/j.xcrm.2023.100956DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152323960URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Luminex data analysis; National Institutes of Health [HG007690, HL155107]; American Heart Association [957729, D007382]; EU Horizon Health [2021, 101057619]; Ruggeri Network Medicine Research Fund; Swedish Cancer Society [CAN 2017/411]; Research Council of Norway, under the frame of Nord-forsk [90825]; Basic Science Research Program through the Na-tional Research Foundation of Korea (NRF) - Korea govern-ment (Ministry of Science and information communication technology (ICT)) [NRF-2021R1A2C1010082]; Yonsei Univer-sity Wonju College of Medicine [2022-52-0054]; Swedish Research Council VR grant [2019-01165, 82171791]; Swedish Rheumatism Association [R-939149]; Region Ostergtland (ALF grant RO?) [-960604]; Ulla and Roland Gustafsson Foundation; King Gustaf Vs 80-Year Anniversary Foundation [FAI-2020-0663]
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Prioritization of disease mechanisms, biomarkers, and drug targets in immune-mediated inflammatory dis-eases (IMIDs) is complicated by altered interactions between thousands of genes. Our multi-organ single -cell RNA sequencing of a mouse IMID model, namely collagen-induced arthritis, shows highly complex and heterogeneous expression changes in all analyzed organs, even though only joints showed signs of inflammation. We organized those into a multi-organ multicellular disease model, which shows predicted mo-lecular interactions within and between organs. That model supports that inflammation is switched on or off by altered balance between pro-and anti-inflammatory upstream regulators (URs) and downstream path-ways. Meta-analyses of human IMIDs show a similar, but graded, on/off switch system. This system has the potential to prioritize, diagnose, and treat optimal combinations of URs on the levels of IMIDs, subgroups, and individual patients. That potential is supported by UR analyses in more than 600 sera from patients with systemic lupus erythematosus.
Subject headings and genre
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Li, XinxiuKarolinska Institutet,Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Karolinska Inst, Sweden(Swepub:liu)xinli70
(author)
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Smelik, MartinLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Karolinska Inst, Sweden(Swepub:liu)marsm05
(author)
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Lee, Eun JungYonsei Univ, South Korea
(author)
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Loscalzo, JosephBrigham & Womens Hosp, MA 02115 USA; Harvard Med Sch, MA 02115 USA
(author)
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Marthanda, Pratheek BellurIcahn Sch Med Mt Sinai, NY 10029 USA
(author)
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Hu, LangXuzhou Med Univ, Peoples R China
(author)
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Magnusson, MattiasKarolinska Institutet
(author)
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Sysoev, OlegLinköpings universitet,Statistik och maskininlärning,Filosofiska fakulteten(Swepub:liu)olesy12
(author)
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Zhang, HuanLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus(Swepub:liu)huazh47
(author)
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Zhao, YelinLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Karolinska Inst, Sweden(Swepub:liu)yelzh67
(author)
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Sjöwall, ChristopherLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93
(author)
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Gawel, DanutaMavatar Inc, Sweden(Swepub:liu)danga10
(author)
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Wang, HuiXuzhou Med Univ, Peoples R China
(author)
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Benson, MikaelLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus,Karolinska Inst, Sweden(Swepub:liu)mikbe05
(author)
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Linköpings universitetAvdelningen för barns och kvinnors hälsa
(creator_code:org_t)
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In:Cell Reports Medicine: ELSEVIER4:32666-3791
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Lilja, Sandra
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Li, Xinxiu
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Smelik, Martin
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Lee, Eun Jung
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Loscalzo, Joseph
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Marthanda, Prath ...
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Hu, Lang
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Magnusson, Matti ...
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Sysoev, Oleg
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Zhang, Huan
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Zhao, Yelin
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Sjöwall, Christo ...
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Gawel, Danuta
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Wang, Hui
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Benson, Mikael
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Linköping University
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Karolinska Institutet