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[C-11]PBB3 binding ...
[C-11]PBB3 binding in A beta(-) or A beta(+) corticobasal syndrome
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- Cselenyi, Zsolt (author)
- Karolinska Inst, Sweden; AstraZeneca, Sweden
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- Wallin, Johan (author)
- Karolinska Inst, Sweden
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- Tjerkoski, Jonathan (author)
- Karolinska Inst, Sweden
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- Bloth, Bjorn (author)
- Karolinska Inst, Sweden
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- Svensson, Samuel (author)
- Linköpings universitet,Kemi,Tekniska fakulteten,Karolinska Inst, Sweden
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- Nennesmo, Inger (author)
- Karolinska Inst, Sweden
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- Sunnemark, Dan (author)
- Karolinska Inst, Sweden
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- Jelic, Vesna (author)
- Karolinska Inst, Sweden
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- Farde, Lars (author)
- Karolinska Inst, Sweden
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- Svenningsson, Per (author)
- Karolinska Inst, Sweden
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(creator_code:org_t)
- 2023-03-23
- 2023
- English.
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In: Synapse. - : Wiley. - 0887-4476 .- 1098-2396. ; 77:4
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Corticobasal syndrome (CBS) is associated with 4-repeat tauopathy and/or Alzheimers disease pathologies. To examine tau and amyloid-beta (A beta) deposits in CBS patients using positron emission tomography (PET). Eight CBS patients and three healthy individuals lacking amyloid pathology underwent PET with [C-11]PBB3 for tau imaging, and [C-11]AZD2184 for A beta. Subcortical and cortical binding of [C-11]PBB3 was compared between A beta(-) and A beta(+) CBS patients and reference group. Postmortem analysis was done in one CBS patient. Three CBS patients were considered A beta(+). Total binding was higher in all patients compared to the reference group. Similar regional binding profiles of [C-11]PBB3 in A beta(+) and A beta(-) CBS patients were found. Elevated [C-11]PBB3 binding in pallidum was observed in all CBS patients. Cortical [C-11]PBB3 binding was higher in A beta(+) compared to A beta(-) patients. Postmortem analysis of a CBS patient revealed corticobasal degeneration neuropathology and [C-11]PBB3 autofluorescence in some tau-positive structures. [C-11]PBB3 is elevated in CBS patients with binding in relevant areas capturing some, but not all, 4-repeat tauopathy in CBS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- amyloid; corticobasal syndrome; PBB3; pet; tau
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cselenyi, Zsolt
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Wallin, Johan
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Tjerkoski, Jonat ...
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Bloth, Bjorn
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Svensson, Samuel
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Nennesmo, Inger
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Sunnemark, Dan
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Jelic, Vesna
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Farde, Lars
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Svenningsson, Pe ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- By the university
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Linköping University