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3D blood-brain barr...
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Adams, YvonneUniv Copenhagen, Denmark
(author)
3D blood-brain barrier-organoids as a model for Lyme neuroborreliosis highlighting genospecies dependent organotropism
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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CELL PRESS,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-194835
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-194835URI
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https://doi.org/10.1016/j.isci.2022.105838DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Danish Ministry of Food, Agriculture and Fisheries (3R-Center Research Grant); Lundbeck Foundation [R180-2014-3098, R313-2019-322, R324-2019-2029]; LundbeckFoundation [R366-2021-127]; European Union through the European Regional Development Fund; Interreg NorthSea Region Program 2014-2020 as part of the NorthTick project; [38-2-7-19]
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Lyme neuroborreliosis (LNB), a tick-borne infection caused by spirochetes within the Borrelia burgdorferi sensu lato (s.L.) complex, is among the most prevalent bacterial central nervous system (CNS) infections in Europe and the US. Here we have screened a panel of low- passage B. burgdorferi s.l. isolates using a novel, human-derived 3D blood-brain barrier (BBB)-organoid model. We show that human-derived BBB-organoids support the entry of Borrelia spirochetes, leading to swelling of the organoids and a loss of their structural integrity. The use of the BBB-organoid model highlights the organotropism between B. burgdorferi s.l. genospecies and their ability to cross the BBB contributing to CNS infection.
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Clausen, Anne SkovsboCopenhagen Univ Hosp, Denmark; Copenhagen Univ Hosp, Denmark
(author)
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Jensen, Peter Ostrup
(author)
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Lager, MalinLinköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Natl Reference Lab Borrel, Div Clin Microbiol, Other Tick Borne Bacter, Lab Med, Reg Jonkoping Cty, Jonkoping, Sweden(Swepub:liu)malch76
(author)
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Wilhelmsson, PeterLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Natl Reference Lab Borrel, Div Clin Microbiol, Other Tick Borne Bacter, Lab Med, Reg Jonkoping Cty, Jonkoping, Sweden(Swepub:liu)petwi60
(author)
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Henningsson, Anna J.,1972-Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Natl Reference Lab Borrel, Div Clin Microbiol, Other Tick Borne Bacter, Lab Med, Reg Jonkoping Cty, Jonkoping, Sweden(Swepub:liu)annjo26
(author)
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Lindgren, Per-EricLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Natl Reference Lab Borrel, Div Clin Microbiol, Other Tick Borne Bacter, Lab Med, Reg Jonkoping Cty, Jonkoping, Sweden(Swepub:liu)perli15
(author)
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Faurholt-Jepsen, DanielCopenhagen Univ Hosp, Denmark
(author)
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Mens, HeleneCopenhagen Univ Hosp, Denmark
(author)
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Kraiczy, PeterGoethe Univ Frankfurt, Germany
(author)
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Kragh, Kasper NorskovCopenhagen Univ Hosp, Denmark; Univ Copenhagen, Denmark
(author)
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Bjarnsholt, ThomasCopenhagen Univ Hosp, Denmark; Univ Copenhagen, Denmark
(author)
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Kjaer, AndreasCopenhagen Univ Hosp, Denmark; Copenhagen Univ Hosp, Denmark
(author)
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Lebech, Anne-MetteCopenhagen Univ Hosp, Denmark; Univ Copenhagen, Denmark
(author)
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Jensen, Anja R.Univ Copenhagen, Denmark
(author)
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Univ Copenhagen, DenmarkCopenhagen Univ Hosp, Denmark; Copenhagen Univ Hosp, Denmark
(creator_code:org_t)
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In:ISCIENCE: CELL PRESS26:12589-0042
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