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Post-COVID sequelae...
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Hannestad, UlfLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
(author)
Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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FRONTIERS MEDIA SA,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-196748
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196748URI
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https://doi.org/10.3389/fmed.2023.1208181DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:153184956URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus, e.g., SARS-CoV-2 in long COVID patients tissues, immune dysregulation with or without reactivation of underlying pathogens, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV6), as we recently described in ME/CFS, and possibly yet unidentified viruses. In the present study we tested saliva samples from two cohorts for IgG against human adenovirus (HAdV): patients with ME/CFS (n = 84) and healthy controls (n = 94), with either mild/asymptomatic SARS-CoV-2 infection or no infection. A significantly elevated anti-HAdV IgG response after SARS-CoV-2 infection was detected exclusively in the patient cohort. Longitudinal/time analysis, before and after COVID-19, in the very same individuals confirmed HAdV IgG elevation after. In plasma there was no HAdV IgG elevation. We conclude that COVID-19 triggered reactivation of dormant HAdV in the oral mucosa of chronic fatigue patients indicating an exhausted dysfunctional antiviral immune response in ME/CFS, allowing reactivation of adenovirus upon stress encounter such as COVID-19. These novel findings should be considered in clinical practice for identification of patients that may benefit from therapy that targets HAdV as well.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Apostolou, EiriniLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)eirap47
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Sjogren, PerKarolinska Inst, Sweden; Bragee Clin, Sweden
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Bragee, BjornKarolinska Inst, Sweden; Bragee Clin, Sweden
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Polo, OlliBragee Clin, Sweden
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Bertilson, Bo ChristerKarolinska Inst, Sweden; Bragee Clin, Sweden
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Rosén, AndersLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)andro72
(author)
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Linköpings universitetAvdelningen för cellbiologi
(creator_code:org_t)
Related titles
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In:Frontiers in Medicine: FRONTIERS MEDIA SA102296-858X
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