Plasma Osteopontin Reflects Tissue Damage in Acute Pancreatitis

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Wirestam, LinaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten (author)

Plasma Osteopontin Reflects Tissue Damage in Acute Pancreatitis

Article/chapterEnglish2023

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MDPI,2023
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LIBRIS-ID:oai:DiVA.org:liu-196877
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196877URI
https://doi.org/10.3390/biomedicines11061627DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies|Swedish Rheumatism Association [R-939149]; Region OEstergoetland (ALF Grants); Gustafsson Foundation [36/2022]; King Gustaf Vs 80-year Anniversary foundation [FAI-2020-0663]; King Gustaf V and Queen Victorias Freemasons foundation
Several scoring systems for clinical prediction of the severity of acute pancreatitis (AP) have been proposed. Yet, there is still a need for an easy-to-measure biomarker. Osteopontin (OPN) may be released to the circulation early during tissue injury, but the significance of OPN in AP has not yet been established. We aimed to evaluate plasma levels of OPN in relation to the severity of AP. In 39 individuals with confirmed AP, plasma was collected on the day of admission and consecutively for three days thereafter. Sex- and age-matched healthy blood donors (n = 39) served as controls. Plasma OPN was measured by a commercial enzyme-linked immunosorbent assay. At admission, patients with AP displayed higher OPN, 156.4 ng/mL (IQR 111.8-196.2) compared to controls, 37.4 ng/mL (IQR 11.7-65.7) (p < 0.0001). However, OPN levels on admission could not discriminate between mild and moderate-to-severe disease (132.6 ng/mL vs. 163.4 ng/mL). Nevertheless, the changes in OPN within 24 h of admission and Day 2/3 were higher among patients with moderate/severe AP (33.7%) compared to mild AP (-8.1%) (p = 0.01). This indicates that OPN is a relevant biomarker reflecting tissue injury in AP. The increase in OPN over time suggests that serial OPN measurements could contribute to the early detection of at-risk patients. Prospective studies assessing OPN in relation to outcome in AP are warranted.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Klinisk laboratoriemedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Clinical Laboratory Medicine hsv//eng
osteopontin; acute pancreatitis; organ damage; biomarker

Added entries (persons, corporate bodies, meetings, titles ...)

Benjaminsson Nyberg, PernillaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)perbe66 (author)
Dzhendov, TodorLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)toddz67 (author)
Gasslander, ThomasLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)thoga06 (author)
Sandström, PerLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)persa07 (author)
Sjöwall, ChristopherLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93 (author)
Björnsson, BergthorLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)berbj34 (author)
Linköpings universitetAvdelningen för inflammation och infektion (creator_code:org_t)

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In:Biomedicines: MDPI11:62227-9059

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