Diffusivity-limited q-space trajectory imaging

Boito, Deneb,1993-Linköpings universitet,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för medicinsk teknik (author)

Funding agencies: This research was funded by Sweden’s Innovation Agency (VINNOVA) ASSIST, Analytic Imaging Diagnostic Arena (AIDA), Swedish Foundation for Strategic Research (RMX18-0056), Linköping University Center for Industrial Information Technology (CENIIT), LiU Cancer Barncancerfonden, and a research grant (00028384) from VILLUM FONDEN.
Q-space trajectory imaging (QTI) allows non-invasive estimation of microstructural features of heterogeneous porous media via diffusion magnetic resonance imaging performed with generalised gradient waveforms. A recently proposed constrained estimation framework, called QTI+, improved QTI’s resilience to noise and data sparsity, thus increasing the reliability of the method by enforcing relevant positivity constraints. In this work we consider expanding the set of constraints to be applied during the fitting of the QTI model. We show that the additional conditions, which introduce an upper bound on the diffusivity values, further improve the retrieved parameters on a publicly available human brain dataset as well as on data acquired from healthy volunteers using a scanner-ready protocol.

TEKNIK OCH TEKNOLOGIER Medicinteknik hsv//swe
ENGINEERING AND TECHNOLOGY Medical Engineering hsv//eng
NATURVETENSKAP Matematik hsv//swe
NATURAL SCIENCES Mathematics hsv//eng
Diffusion; Diffusion MRI; q-space trajectory imaging; QTI; Microstructure; Microscopic anisotropy; QTI+Constrained

Herberthson, Magnus,1963-Linköpings universitet,Tekniska fakulteten,Algebra, geometri och diskret matematik(Swepub:liu)maghe04 (author)
Dela Haije, TomUniversity of Copenhagen, Denmark (author)
Blystad, Ida,1972-Linköpings universitet,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för diagnostik och specialistmedicin,Region Östergötland, Röntgenkliniken i Linköping(Swepub:liu)idabl62 (author)
Özarslan, Evren,1976-Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)evroz77 (author)
Linköpings universitetTekniska fakulteten (creator_code:org_t)

In:Magnetic Resonance Letters: KeAi Publishing Communications3:2, s. 187-1962772-5162

By the author/editor: Boito, Deneb, 19 ...; Herberthson, Mag ...; Dela Haije, Tom; Blystad, Ida, 19 ...; Özarslan, Evren, ...

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