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Cis P-tau is a cent...
Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia
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- Jash, Sukanta (author)
- Brown Univ, RI 02905 USA
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- Banerjee, Sayani (author)
- Brown Univ, RI 02905 USA
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- Cheng, Shibin (author)
- Brown Univ, RI 02905 USA
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- Wang, Bin (author)
- Harvard Med Sch, MA 02215 USA
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- Qiu, Chenxi (author)
- Harvard Med Sch, MA 02215 USA
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- Kondo, Asami (author)
- Harvard Med Sch, MA 02215 USA
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- Ernerudh, Jan (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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- Zhou, Xiao Zhen (author)
- Western Univ, Canada
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- Lu, Kun Ping (author)
- Western Univ, Canada
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- Sharma, Surendra (author)
- Brown Univ, RI 02905 USA
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(creator_code:org_t)
- NATURE PORTFOLIO, 2023
- 2023
- English.
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In: Nature Communications. - : NATURE PORTFOLIO. - 2041-1723. ; 14:1
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Preeclampsia (PE) is the leading cause of maternal and fetal mortality globally and may trigger dementia later in life in mothers and their offspring. However, the etiological drivers remain elusive. Cis P-tau is an early etiological driver and blood biomarker in pre-clinical Alzheimers and after vascular or traumatic brain injury, which can be targeted by stereo-specific antibody, with clinical trials ongoing. Here we find significant cis P-tau in the placenta and serum of PE patients, and in primary human trophoblasts exposed to hypoxia or sera from PE patients due to Pin1 inactivation. Depletion of cis P-tau from PE patient sera by the antibody prevents their ability to disrupt trophoblast invasion and endovascular activity and to cause the PE-like pathological and clinical features in pregnant humanized tau mice. Our studies uncover that cis P-tau is a central circulating etiological driver and its stereo-specific antibody is valuable for early PE diagnosis and treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jash, Sukanta
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Banerjee, Sayani
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Cheng, Shibin
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Wang, Bin
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Qiu, Chenxi
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Kondo, Asami
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show more...
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Ernerudh, Jan
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Zhou, Xiao Zhen
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Lu, Kun Ping
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Sharma, Surendra
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature Communica ...
- By the university
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Linköping University