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Pleconaril and riba...
Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial
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- Krogvold, Lars (author)
- Oslo Univ Hosp, Norway
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- Mynarek, Ida Maria (author)
- Oslo Univ Hosp, Norway
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- Ponzi, Erica (author)
- Oslo Univ Hosp, Norway
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- Mork, Freja Barrett (author)
- Copenhagen Univ Hosp, Denmark; Univ Copenhagen, Denmark
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- Hessel, Trine Witzner (author)
- Copenhagen Univ Hosp, Denmark
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- Roald, Trine (author)
- Oslo Univ Hosp, Norway
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- Lindblom, Nina (author)
- Apodemus AB, Sweden
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- Westman, Jacob (author)
- Apodemus AB, Sweden
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- Barker, Peter (author)
- Natl Inst Hlth & Care Res, England
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- Hyoety, Heikki (author)
- Tampere Univ, Finland; Fimlab Labs, Finland
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- Ludvigsson, Johnny (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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- Hanssen, Kristian F. (author)
- Univ Oslo, Norway
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- Johannesen, Jesper (author)
- Copenhagen Univ Hosp, Denmark
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- Dahl-Jorgensen, Knut (author)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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(creator_code:org_t)
- NATURE PORTFOLIO, 2023
- 2023
- English.
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In: Nature Medicine. - : NATURE PORTFOLIO. - 1078-8956 .- 1546-170X. ; 29, s. 2902-2908
- Related links:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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Abstract
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- Previous studies showed a low-grade enterovirus infection in the pancreatic islets of patients with newly diagnosed type 1 diabetes (T1D). In the Diabetes Virus Detection (DiViD) Intervention, a phase 2, placebo-controlled, randomized, parallel group, double-blind trial, 96 children and adolescents (aged 6-15 years) with new-onset T1D received antiviral treatment with pleconaril and ribavirin (n = 47) or placebo (n = 49) for 6 months, with the aim of preserving beta cell function. The primary endpoint was the mean stimulated C-peptide area under the curve (AUC) 12 months after the initiation of treatment (less than 3 weeks after diagnosis) using a mixed linear model. The model used longitudinal log-transformed serum C-peptide AUCs at baseline, at 3 months, 6 months and 1 year. The primary endpoint was met with the serum C-peptide AUC being higher in the pleconaril and ribavirin treatment group compared to the placebo group at 12 months (average marginal effect = 0.057 in the linear mixed model; 95% confidence interval = 0.004-0.11, P = 0.037). The treatment was well tolerated. The results show that antiviral treatment may preserve residual insulin production in children and adolescent with new-onset T1D. This provides a rationale for further evaluating antiviral strategies in the prevention and treatment of T1D. European Union Drug Regulating Authorities Clinical Trials identifier: 2015-003350-41. Results from the DiViD Intervention, a phase 2 randomized, placebo-controlled trial, showed that antiviral treatment with pleconaril and ribavirin for 6 months resulted in higher endogenous insulin production in children and adolescents with new-onset type 1 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Krogvold, Lars
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Mynarek, Ida Mar ...
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Ponzi, Erica
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Mork, Freja Barr ...
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Hessel, Trine Wi ...
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Roald, Trine
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Lindblom, Nina
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Westman, Jacob
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Barker, Peter
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Hyoety, Heikki
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Ludvigsson, John ...
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Hanssen, Kristia ...
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Johannesen, Jesp ...
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Dahl-Jorgensen, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature Medicine
- By the university
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Linköping University