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  • Wong, Vincent Wai-SunChinese Univ Hong Kong, Peoples R China (author)

Changing epidemiology, global trends and implications for outcomes of NAFLD

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • ELSEVIER,2023
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:liu-198686
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198686URI
  • https://doi.org/10.1016/j.jhep.2023.04.036DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153909184URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Funding Agencies|Chinese University of Hong Kong [2021.027]; Swedish Research Council [2021-01293]
  • Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common liver disease globally and is currently estimated to affect 38% of the global population. Only a minority of patients with NAFLD will progress to cirrhosis or hepatocellular carcinoma, but from this vast population the total number of patients who are at risk of such severe outcomes is increasing. Worryingly, individuals are increasingly being affected by NAFLD at an earlier age, meaning there is more time for them to develop severe complications. With considerable changes in dietary composition and urbanisation, alongside the growth in obesity and type 2 diabetes in the global population, in particular in developing countries, the global proportion of persons affected by NAFLD is projected to increase further. Yet, there are large geographical discrepancies in the prevalence rates of NAFLD and its inflammatory component non-alcoholic steatohepatitis (NASH). Such differences are partly related to differing socio-economic milieus, but also to genetic predisposition. In this narrative review, we discuss recent changes in the epidemiology of NAFLD and NASH from regional and global perspectives, as well as in special populations. We also discuss the potential consequences of these changes on hepatic and extrahepatic events. (c) 2023 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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  • Ekstedt, MattiasLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)matek92 (author)
  • Wong, Grace Lai-HungChinese Univ Hong Kong, Peoples R China; Prince Wales Hosp, Peoples R China (author)
  • Hagstrom, HannesKarolinska Institutet (author)
  • Chinese Univ Hong Kong, Peoples R ChinaAvdelningen för diagnostik och specialistmedicin (creator_code:org_t)

Related titles

  • In:Journal of Hepatology: ELSEVIER79:3, s. 842-8520168-82781600-0641

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