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Multivariate analys...
Multivariate analyses of immune markers reveal increases in plasma EN-RAGE in first-episode psychosis patients
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- Korhonen, Laura, Professor, 1974- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Barn- och ungdomspsykiatriska kliniken Linköping
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- Paul, Elisabeth, 1991- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Wåhlén, Karin, 1986- (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Haring, Liina (author)
- 5 Institute of Clinical Medicine University of Tartu; Psychiatry Clinic of Tartu University Hospital, Tartu, Estonia
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- Vasar, Eero (author)
- Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia
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- Vaheri, Antti (author)
- 7 Department of Virology, Medicum, University of Helsinki, Finland
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- Lindholm, Dan (author)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Department of Biochemistry and Developmental Biology, Medicum, University of Helsinki, Finland; 9 Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Finland
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(creator_code:org_t)
- Springer, 2023
- 2023
- English.
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In: Translational Psychiatry. - : Springer. - 2158-3188. ; 13:1
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Abstract
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- Immune cells and cytokines are largely recognized as significant factors in the pathophysiology of neuropsychiatric disorders. The possible role of other blood cells such as leukocytes in events of acute psychosis is in contrast only emerging. To study blood-born markers in acute psychosis we here evaluated plasma proteins in drug-naive first-episode psychosis (FEP) patients and healthy controls using a multiplex proximity extension assay technique. We analyzed a panel of 92 immune markers and plasma samples from 60 FEP patients and 50 controls and evaluated the changes obtained using multivariate statistical methods followed by protein pathway analyses. Data showed that 11 proteins are significantly different between FEP patients and healthy controls We observed increases in pro-inflammatory proteins such as interleukin-6, oncostatin-M, and transforming growth factor-alpha in FEP patients compared with controls. Likewise, the extracellular newly identified RAGE-binding protein (EN-RAGE) that regulates the expression of various cytokines was also elevated in the plasma of FEP patients. The results indicate that neutrophil-derived EN-RAGE could play an important role during the early phase of acute psychosis by stimulating cytokines and the immune response targeting thereby likely also the brain vasculature.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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- ref (subject category)
- art (subject category)
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Korhonen, Laura, ...
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Paul, Elisabeth, ...
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Wåhlén, Karin, 1 ...
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Haring, Liina
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Vasar, Eero
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Vaheri, Antti
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Lindholm, Dan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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Translational Ps ...
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Linköping University