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Up-to-date molecular medicine strategies for management of ocular surface neovascularization
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- Yang, Yunlong (author)
- Fudan Univ, Peoples R China
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- Zhong, Junmu (author)
- Fujian Med Univ, Peoples R China
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- Cui, Dongmei (author)
- Jinan Univ, Peoples R China
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- (creator_code:org_t)
- ELSEVIER, 2023
- 2023
- English.
- In: Advanced Drug Delivery Reviews. - : ELSEVIER. - 0169-409X .- 1872-8294. ; 201
- Research review (peer-reviewed)
Abstract
Subject headings
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- Ocular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct the light path to the retina, and hence is a major cause of vision loss. Various factors such as infection, irritation, trauma, dry eye, and ocular surface surgery trigger neovascularization via angiogenesis and lym-phangiogenesis dependent on VEGF-related and alternative mechanisms. Recent advances in antiangiogenic drugs, nanotechnology, gene therapy, surgical equipment and techniques, animal models, and drug delivery strategies have provided a range of novel therapeutic options for the treatment of ocular surfaceneovascularization. In this review article, we comprehensively discuss the etiology and mechanisms of corneal neovascularization and other types of ocular surface neovascularization, as well as emerging animal models and drug delivery strategies that facilitate its management.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Ocular surface; Corneal neovascularization; Angiogenesis; Drug delivery; Animal models
Publication and Content Type
- ref (subject category)
- for (subject category)
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- Yang, Yunlong
- Zhong, Junmu
- Cui, Dongmei
- Jensen, Lasse
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
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- By the university
- Linköping University
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