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Machine-learning an...
Machine-learning analysis of cross-study samples according to the gut microbiome in 12 infant cohorts
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- Vaenni, Petri (author)
- Univ Oulu, Finland
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- Tejesvi, Mysore V. (author)
- Univ Oulu, Finland
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- Paalanne, Niko (author)
- Univ Oulu, Finland; Oulu Univ Hosp, Finland
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- Aagaard, Kjersti (author)
- Baylor Coll Med, TX USA; Texas Childrens Hosp, TX USA
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- Ackermann, Gail (author)
- Univ Calif San Diego, CA USA
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- Camargo, Carlos A. (author)
- Harvard Med Sch, MA USA
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- Eggesbo, Merete (author)
- Norwegian Inst Publ Hlth, Norway; Norwegian Univ Sci & Technol, Norway
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- Hasegawa, Kohei (author)
- Harvard Med Sch, MA USA
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- Hoen, Anne G. (author)
- Dartmouth Coll, NH USA
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- Karagas, Margaret R. (author)
- Dartmouth Coll, NH USA
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- Kolho, Kaija-Leena (author)
- Univ Helsinki, Finland; HUS, Finland
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- Laursen, Martin F. (author)
- Tech Univ Denmark, Denmark
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- Ludvigsson, Johnny (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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- Madan, Juliette (author)
- Dartmouth Hitchcock Med Ctr, NH USA
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- Ownby, Dennis (author)
- Med Coll Georgia, GA USA
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- Stanton, Catherine (author)
- Teagasc Food Res Ctr, Ireland; APC Microbiome Ireland, Ireland
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- Stokholm, Jakob (author)
- Univ Copenhagen, Denmark
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- Tapiainen, Terhi (author)
- Univ Oulu, Finland; Baylor Coll Med, TX USA; Texas Childrens Hosp, TX USA
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(creator_code:org_t)
- AMER SOC MICROBIOLOGY, 2023
- 2023
- English.
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In: mSystems. - : AMER SOC MICROBIOLOGY. - 2379-5077. ; 8:6
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Combining and comparing microbiome data from distinct infant cohorts has been challenging because such data are inherently multidimensional and complex. Here, we used an ensemble of machine-learning (ML) models and studied 16S rRNA amplicon sequencing data from 4,099 gut microbiome samples representing 12 prospectively collected infant cohorts. We chose the childbirth delivery mode as a starting point for such analysis because it has previously been associated with alterations in the gut microbiome in infants. In cross-study ensemble models, Bacteroides was the most important feature in all machine-learning models. The predictive capacity by taxonomy varied with age. At the age of 1-2 months, gut microbiome data were able to predict delivery mode with an area under the curve of 0.72 to 0.83. In contrast, ML models trained on taxa were not able to differentiate between the modes of delivery, in any of the cohorts, when the infants were between 3 and 12 months of age. Moreover, no ML model, alternately trained on the functional pathways of the infant gut microbiome, could consistently predict mode of delivery at any infant age. This study shows that infant gut microbiome data sets can be effectively combined with the application of ML analysis across different study populations.IMPORTANCEThere are challenges in merging microbiome data from diverse research groups due to the intricate and multifaceted nature of such data. To address this, we utilized a combination of machine-learning (ML) models to analyze 16S sequencing data from a substantial set of gut microbiome samples, sourced from 12 distinct infant cohorts that were gathered prospectively. Our initial focus was on the mode of delivery due to its prior association with changes in infant gut microbiomes. Through ML analysis, we demonstrated the effective merging and comparison of various gut microbiome data sets, facilitating the identification of robust microbiome biomarkers applicable across varied study populations.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Keyword
- machine learning; bioinformatics; human microbiome; gut microbiome; random forest; infant; children; cross-study; ensemble
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vaenni, Petri
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Tejesvi, Mysore ...
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Paalanne, Niko
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Aagaard, Kjersti
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Ackermann, Gail
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Camargo, Carlos ...
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show more...
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Eggesbo, Merete
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Hasegawa, Kohei
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Hoen, Anne G.
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Karagas, Margare ...
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Kolho, Kaija-Lee ...
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Laursen, Martin ...
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Ludvigsson, John ...
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Madan, Juliette
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Ownby, Dennis
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Stanton, Catheri ...
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Stokholm, Jakob
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Tapiainen, Terhi
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
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mSystems
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Linköping University