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Prostaglandin produ...
Prostaglandin production in brain endothelial cells during the initiation of fever
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- Eskilsson, Anna, 1986- (author)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för neurobiologi
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- Shionoya, Kiseko, 1964- (author)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för neurobiologi
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- Blomqvist, Anders, 1949- (author)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för neurobiologi
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(creator_code:org_t)
- 2023-01-11
- 2023
- English.
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In: Communicative & Integrative Biology. - : Informa UK Limited. - 1942-0889. ; 16:1
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The initiation of fever has been a matter of controversy. Based on observations of little or no induction of prostaglandin synthesizing enzymes in the brain during the first phase of fever it was suggested that fever is initiated by prostaglandin released into the circulation from cells in the liver and lungs. Here we show in the mouse that prostaglandin synthesis is rapidly induced in the brain after immune challenge. These data are consistent with our recent findings in functional experiments that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of all phases of fever.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Cyclooxygenase-2; brain vascular cells; lipopolysaccharide; microsomal prostaglandin E synthase-1; myeloid cells; prostaglandin E2
Publication and Content Type
- ref (subject category)
- art (subject category)
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