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Serum ferritin leve...
Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
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- Armandi, Angelo (author)
- Univ Turin, Italy; Univ Med Ctr, Germany
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- Sanavia, Tiziana (author)
- Univ Turin, Italy
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- Younes, Ramy (author)
- Boehringer Ingelheim Int GmbH, Germany
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- Caviglia, Gian Paolo (author)
- Univ Turin, Italy
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- Rosso, Chiara (author)
- Univ Turin, Italy
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- Govaere, Olivier (author)
- Newcastle Univ, England
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- Liguori, Antonio (author)
- Fdn Policlin Univ A Gemelli IRCCS, Italy; Fdn Policlin Univ A Gemelli IRCCS, Italy; Univ Cattolica Sacro Cuore, Italy
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- Francione, Paolo (author)
- Fdn IRCCS Ca Granda Osped Maggiore Policlin, Italy
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- Gallego-Duran, Rocio (author)
- Virgen Rocio Univ Hosp, Spain
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- Ampuero, Javier (author)
- Virgen Rocio Univ Hosp, Spain
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- Pennisi, Grazia (author)
- Univ Palermo, Italy
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- Aller, Rocio (author)
- Hosp Clin Valladolid, Spain
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- Tiniakos, Dina (author)
- Newcastle Univ, England; Natl & Kapodistrian Univ Athens, Greece
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- Burt, Alastair (author)
- Newcastle Univ, England
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- David, Ezio (author)
- Univ Turin, Italy
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- Vecchio, Fabio (author)
- Dipartimento Univ Med & Chirurg Traslazionale, Italy
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- Maggioni, Marco (author)
- Ca Granda IRCCS Fdn, Italy
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- Cabibi, Daniela (author)
- Univ Palermo, Italy
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- Mcleod, Duncan (author)
- Westmead Hosp, Australia
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- Pareja, Maria Jesus (author)
- Hosp Univ Valme, Spain
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- Zaki, Marco Y. W. (author)
- Newcastle Univ, England; Minia Univ, Egypt
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- Stal, Per (author)
- Karolinska Univ Hosp, Sweden; Huddinge Karolinska Inst, Sweden
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- Kechagias, Stergios (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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- Fracanzani, Anna Ludovica (author)
- Fdn IRCCS Ca Granda Osped Maggiore Policlin, Italy; Univ Milan, Italy
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- Valenti, Luca (author)
- Univ Milan, Italy; Fdn IRCCS Ca Granda Osped Maggiore Policlin Milano, Italy
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- Grieco, Antonio (author)
- Dipartimento Univ Med & Chirurg Traslazionale, Italy
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- Miele, Luca (author)
- Fdn Policlin Univ A Gemelli IRCCS, Italy; Fdn Policlin Univ A Gemelli IRCCS, Italy; Univ Cattolica Sacro Cuore, Italy
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- Fariselli, Piero (author)
- Univ Turin, Italy
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- Eslam, Mohammed (author)
- Univ Sydney, Australia
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- Petta, Salvatore (author)
- Univ Palermo, Italy
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- Hagstroem, Hannes (author)
- Karolinska Univ Hosp, Sweden; Huddinge Karolinska Inst, Sweden
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- George, Jacob (author)
- Univ Sydney, Australia
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- Schattenberg, Joern M. (author)
- Univ Med Ctr, Germany; Saarland Univ, Germany
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- Romero-Gomez, Manuel (author)
- Virgen Rocio Univ Hosp, Spain
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- Anstee, Quentin Mark (author)
- Newcastle Univ, England; Newcastle Tyne Hosp NHS Fdn Trust, England
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- Bugianesi, Elisabetta (author)
- Univ Turin, Italy
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Gut. - : BMJ PUBLISHING GROUP. - 0017-5749 .- 1468-3288.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell's C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of liver-related events and 27% of all-cause mortality. A stepwise increase in baseline ferritin thresholds was associated with a statistical increase in C-index, ranging between 0.02 (lasso-penalised Cox regression) and 0.03 (ridge-penalised Cox regression); the risk of developing liver-related events mainly increased from threshold 215.5 mu g/L (median HR=1.71 and C-index=0.71) and the risk of overall mortality from threshold 272 mu g/L (median HR=1.49 and C-index=0.70). The inclusion of serum ferritin thresholds (215.5 mu g/L and 272 mu g/L) in predictive models increased the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score in the longitudinal risk assessment of liver-related events (C-indices>0.71) and overall mortality (C-indices>0.65). Conclusions This study supports the potential use of serum ferritin values for predicting the long-term prognosis of patients with MASLD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- NONALCOHOLIC STEATOHEPATITIS; FIBROSIS
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Armandi, Angelo
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Sanavia, Tiziana
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Younes, Ramy
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Caviglia, Gian P ...
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Rosso, Chiara
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Govaere, Olivier
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show more...
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Liguori, Antonio
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Francione, Paolo
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Gallego-Duran, R ...
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Ampuero, Javier
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Pennisi, Grazia
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Aller, Rocio
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Tiniakos, Dina
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Burt, Alastair
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David, Ezio
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Vecchio, Fabio
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Maggioni, Marco
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Cabibi, Daniela
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Mcleod, Duncan
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Pareja, Maria Je ...
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Zaki, Marco Y. W ...
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Stal, Per
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Kechagias, Sterg ...
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Fracanzani, Anna ...
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Valenti, Luca
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Grieco, Antonio
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Miele, Luca
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Fariselli, Piero
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Eslam, Mohammed
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Petta, Salvatore
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Hagstroem, Hanne ...
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George, Jacob
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Schattenberg, Jo ...
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Romero-Gomez, Ma ...
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Anstee, Quentin ...
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Bugianesi, Elisa ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Gut
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Linköping University
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Karolinska Institutet