Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity

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Sangchooli, ArshiyaUniv Melbourne, Australia (author)

Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity

Article/chapterEnglish2024

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2024
AMER MEDICAL ASSOC,2024
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LIBRIS-ID:oai:DiVA.org:liu-201166
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201166URI
https://doi.org/10.1001/jamapsychiatry.2023.5483DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:for swepub-publicationtype

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Funding Agencies|Deutsche Forschungsgemeinschaft
Importance In the last 25 years, functional magnetic resonance imaging drug cue reactivity (FDCR) studies have characterized some core aspects in the neurobiology of drug addiction. However, no FDCR-derived biomarkers have been approved for treatment development or clinical adoption. Traversing this translational gap requires a systematic assessment of the FDCR literature evidence, its heterogeneity, and an evaluation of possible clinical uses of FDCR-derived biomarkers. Objective To summarize the state of the field of FDCR, assess their potential for biomarker development, and outline a clear process for biomarker qualification to guide future research and validation efforts. Evidence Review The PubMed and Medline databases were searched for every original FDCR investigation published from database inception until December 2022. Collected data covered study design, participant characteristics, FDCR task design, and whether each study provided evidence that might potentially help develop susceptibility, diagnostic, response, prognostic, predictive, or severity biomarkers for 1 or more addictive disorders. Findings There were 415 FDCR studies published between 1998 and 2022. Most focused on nicotine (122 [29.6%]), alcohol (120 [29.2%]), or cocaine (46 [11.1%]), and most used visual cues (354 [85.3%]). Together, these studies recruited 19 311 participants, including 13 812 individuals with past or current substance use disorders. Most studies could potentially support biomarker development, including diagnostic (143 [32.7%]), treatment response (141 [32.3%]), severity (84 [19.2%]), prognostic (30 [6.9%]), predictive (25 [5.7%]), monitoring (12 [2.7%]), and susceptibility (2 [0.5%]) biomarkers. A total of 155 interventional studies used FDCR, mostly to investigate pharmacological (67 [43.2%]) or cognitive/behavioral (51 [32.9%]) interventions; 141 studies used FDCR as a response measure, of which 125 (88.7%) reported significant interventional FDCR alterations; and 25 studies used FDCR as an intervention outcome predictor, with 24 (96%) finding significant associations between FDCR markers and treatment outcomes. Conclusions and Relevance Based on this systematic review and the proposed biomarker development framework, there is a pathway for the development and regulatory qualification of FDCR-based biomarkers of addiction and recovery. Further validation could support the use of FDCR-derived measures, potentially accelerating treatment development and improving diagnostic, prognostic, and predictive clinical judgments.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng

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Zare-Bidoky, MehranUniv Minnesota, MN USA; Univ Tehran Med Sci, Iran (author)
Jouzdani, Ali FathiUniv Tehran Med Sci, Iran (author)
Schacht, JosephUniv Colorado, CO USA (author)
Bjork, James M.Virginia Commonwealth Univ, VA USA (author)
Claus, Eric D.Penn State Univ, PA 16802 USA (author)
Prisciandaro, James J.Med Univ South Carolina, SC 29425 USA (author)
Wilson, Stephen J.Penn State Univ, PA USA (author)
Wuestenberg, TorstenHeidelberg Univ, Germany (author)
Potvin, StephaneUniv Montreal, Canada (author)
Ahmadi, PooriaUniv British Columbia, Canada (author)
Bach, PatrickHeidelberg Univ, Germany (author)
Baldacchino, AlexUniv St Andrews, Scotland (author)
Beck, AnneHlth & Med Univ, Germany; Charite Univ Med Berlin, Germany (author)
Brady, Kathleen T.Med Univ South Carolina, SC 29425 USA (author)
Brewer, Judson A.Brown Univ, RI 02912 USA (author)
Childress, Anna RoseUniv Penn, PA 19104 USA (author)
Courtney, Kelly E.Univ Calif San Diego, CA 92103 USA (author)
Ebrahimi, MohsenUniv Tehran Med Sci, Iran (author)
Filbey, Francesca M.Univ Texas Dallas, TX 75083 USA (author)
Garavan, HughUniv Vermont, VT USA (author)
Ghahremani, Dara G.Univ Calif Los Angeles, CA 90024 USA (author)
Goldstein, Rita Z.Icahn Sch Med Mt Sinai, NY 10029 USA; Icahn Sch Med Mt Sinai, NY 10029 USA (author)
Goudriaan, Anneke E.Univ Amsterdam, Netherlands; Amsterdam Neurosci, Netherlands (author)
Grodin, Erica N.Univ Calif Los Angeles, CA 90024 USA (author)
Hanlon, Colleen A.Wake Forest Sch Med, NC 27101 USA; BrainsWay Inc, NC USA (author)
Haugg, AmelieUniv Zurich, Switzerland (author)
Heilig, Markus,1959-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)marhe41 (author)
Heinz, AndreasCharite Univ Med Berlin, Germany (author)
Holczer, AdriennUniv Szeged, Hungary (author)
Van Holst, Ruth J.Univ Amsterdam, Netherlands (author)
Joseph, Jane E.Med Univ South Carolina, SC 29425 USA (author)
Juliano, Anthony C.Univ Vermont, VT USA (author)
Kaufman, Marc J.Harvard Med Sch, MA USA (author)
Kiefer, FalkHeidelberg Univ, Germany (author)
Zonoozi, Arash KhojastehUniv Tehran Med Sci, Iran (author)
Kuplicki, Rayus T.Laureate Inst Brain Res, OK USA (author)
Leyton, MarcoMcGill Univ, Canada (author)
London, Edythe D.Univ Calif Los Angeles, CA 90024 USA (author)
Mackey, ScottUniv Vermont, VT USA (author)
McClernon, F. JosephDuke Univ, NC USA (author)
Mellick, William H.Med Univ South Carolina, SC 29425 USA (author)
Morley, KirstenUniv Sydney, Australia (author)
Noori, Hamid R.MIT, MA 02139 USA (author)
Oghabian, Mohammad AliUniv Tehran Med Sci, Iran (author)
Oliver, Jason A.Univ Oklahoma, OK USA (author)
Owens, MaxUniv Vermont, VT USA (author)
Paulus, Martin P.Laureate Inst Brain Res, OK USA (author)
Perini, Irene,1983-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)irepe41 (author)
Rafei, ParnianUniv Tehran Med Sci, Iran (author)
Ray, Lara A.Univ Calif Los Angeles, CA 90024 USA (author)
Sinha, RajitaYale Sch Med, CT USA (author)
Smolka, Michael N.Tech Univ Dresden, Germany (author)
Soleimani, GhazalehUniv Minnesota, MN USA (author)
Spanagel, RainerCent Inst Mental Hlth, Germany (author)
Steele, Vaughn R.Yale Sch Med, CT USA (author)
Tapert, Susan F.Univ Calif San Diego, CA 92103 USA (author)
Vollstaedt-Klein, SabineHeidelberg Univ, Germany (author)
Wetherill, Reagan R.Univ Penn, PA 19104 USA (author)
Witkiewitz, KatieUniv New Mexico, NM 87131 USA (author)
Yuan, KaiXidian Univ, Peoples R China (author)
Zhang, XiaochuUniv Sci & Technol China, Peoples R China (author)
Verdejo-Garcia, AntonioMonash Univ, Australia (author)
Potenza, Marc N.Tech Univ Dresden, Germany (author)
Janes, Amy C.NIDA, MD USA (author)
Kober, HedyYale Sch Med, CT USA (author)
Zilverstand, AnnaUniv Minnesota, MN USA (author)
Ekhtiari, HamedUniv Minnesota, MN USA; Laureate Inst Brain Res, OK USA (author)
Univ Melbourne, AustraliaUniv Minnesota, MN USA; Univ Tehran Med Sci, Iran (creator_code:org_t)

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By the author/editor: Sangchooli, Arsh ...; Zare-Bidoky, Meh ...; Jouzdani, Ali Fa ...; Schacht, Joseph; Bjork, James M.; Claus, Eric D.; show more...; Prisciandaro, Ja ...; Wilson, Stephen ...; Wuestenberg, Tor ...; Potvin, Stephane; Ahmadi, Pooria; Bach, Patrick; Baldacchino, Ale ...; Beck, Anne; Brady, Kathleen ...; Brewer, Judson A ...; Childress, Anna ...; Courtney, Kelly ...; Ebrahimi, Mohsen; Filbey, Francesc ...; Garavan, Hugh; Ghahremani, Dara ...; Goldstein, Rita ...; Goudriaan, Annek ...; Grodin, Erica N.; Hanlon, Colleen ...; Haugg, Amelie; Heilig, Markus, ...; Heinz, Andreas; Holczer, Adrienn; Van Holst, Ruth ...; Joseph, Jane E.; Juliano, Anthony ...; Kaufman, Marc J.; Kiefer, Falk; Zonoozi, Arash K ...; Kuplicki, Rayus ...; Leyton, Marco; London, Edythe D ...; Mackey, Scott; McClernon, F. Jo ...; Mellick, William ...; Morley, Kirsten; Noori, Hamid R.; Oghabian, Mohamm ...; Oliver, Jason A.; Owens, Max; Paulus, Martin P ...; Perini, Irene, 1 ...; Rafei, Parnian; Ray, Lara A.; Sinha, Rajita; Smolka, Michael ...; Soleimani, Ghaza ...; Spanagel, Rainer; Steele, Vaughn R ...; Tapert, Susan F.; Vollstaedt-Klein ...; Wetherill, Reaga ...; Witkiewitz, Kati ...; Yuan, Kai; Zhang, Xiaochu; Verdejo-Garcia, ...; Potenza, Marc N.; Janes, Amy C.; Kober, Hedy; Zilverstand, Ann ...; Ekhtiari, Hamed; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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