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Mitochondria-target...
Mitochondria-targeted iridium (III) complexes as two-photon fluorogenic probes of cysteine/homocysteine
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- Wang, Hui (author)
- Anhui Univ, Peoples R China
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- Hu, Lei (author)
- Anhui Univ, Peoples R China
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- Du, Wei (author)
- Anhui Univ, Peoples R China
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- Tian, Xiaohe (author)
- Anhui Univ, Peoples R China
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- Hu, Zhangjun (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Zhang, Qiong (author)
- Anhui Univ, Peoples R China
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- Zhou, Hongping (author)
- Anhui Univ, Peoples R China
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- Wu, Jieying (author)
- Anhui Univ, Peoples R China
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- Uvdal, Kajsa (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Tian, Yupeng (author)
- Anhui Univ, Peoples R China; Nanjing Univ, Peoples R China
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(creator_code:org_t)
- ELSEVIER SCIENCE SA, 2018
- 2018
- English.
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In: Sensors and actuators. B, Chemical. - : ELSEVIER SCIENCE SA. - 0925-4005 .- 1873-3077. ; 255, s. 408-415
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Fluorescent imaging of cysteine (Cys) and homocysteine (Hcy) is crucial to understand sulphur metabolism in living cells. Whereas two-photon active cyclometalated Ir(III) complex for detecting Cys/Hcy has been rarely reported. Herein, two novel cyclometalated iridium (III) complexes Ir1-1r2 with different electron-donor were designed, synthesized and fully characterized as well as confirmed by single-crystal X-ray diffraction analysis, which could selectively react with Cys/Hcy, accompanying with an obvious one- and two-photon fluorescence enhancement in vitro. The mechanism for sensing Cys/Hcy was further analyzed in detail by mass spectra and time-dependent density functional theory calculations. It was found that Ir2, bearing ester group, exhibited higher performance on the selective detection of Cys and Hcy compared to In. Notably, the two-photon action cross-section value in the near-infrared region (similar to 800 nm) of Ir2 is significantly enhanced upon the addition of Cys/Hcy. Further application to cellular imaging indicated that Ir2 is membrane permeable and capable of monitoring the changes of intracellular mitochondrial Cys/Hcy. These results support that such two-photon active complexes might provide a promising platform for the detection of mitochondrial Cys/Hcy in living biological systems. (C) 2017 Published by Elsevier B.V.
Subject headings
- NATURVETENSKAP -- Fysik -- Atom- och molekylfysik och optik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Atom and Molecular Physics and Optics (hsv//eng)
Keyword
- Iridium complexes; Terpyridine; Two-photon fluorescence; Mitochondria; Cysteine; Homocysteine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wang, Hui
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Hu, Lei
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Du, Wei
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Tian, Xiaohe
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Hu, Zhangjun
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Zhang, Qiong
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show more...
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Zhou, Hongping
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Wu, Jieying
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Uvdal, Kajsa
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Tian, Yupeng
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Atom and Molecul ...
- Articles in the publication
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Sensors and actu ...
- By the university
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Linköping University