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Bergstrand, SaraLinköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten
(author)
Association between cardiovascular risk profile and impaired microvascular function in a Swedish middle-aged cohort (the SCAPIS study)
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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2024
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OXFORD UNIV PRESS,2024
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-201475
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201475URI
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https://doi.org/10.1093/eurjpc/zwae052DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council [2021-06432, 2021-03690]; Swedish Heart-Lung Foundation [20210184]; Sweden's innovation agency (VINNOVA) via the programme MedTech4Health [2016-02211]; Knut and Alice Wallenberg Foundation; VINNOVA; University of Gothenburg; Sahlgrenska University Hospital; Karolinska Institutet; Stockholm County Council; Linkoping University; University Hospital; Lund University; Skane University Hospital; Umea University; Uppsala University
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Aims The aim was to investigate the relationship between microvascular function, cardiovascular risk profile, and subclinical atherosclerotic burden. Methods and results The study enrolled 3809 individuals, 50-65 years old, participating in the population-based observational cross-sectional Swedish CArdioPulmonary bioImage Study. Microvascular function was assessed in forearm skin using an arterial occlusion and release protocol determining peak blood oxygen saturation (OxyP). Cardiovascular risk was calculated using the updated Systematic Coronary Risk Evaluation [SCORE2; 10-year risk of fatal and non-fatal cardiovascular disease (CVD) events]. The OxyP was compared with coronary artery calcification score (CACS) and to plaques in the carotid arteries. Individuals with OxyP values in the lowest quartile (Q1; impaired microvascular function) had a mean SCORE2 of 5.8% compared with 3.8% in those with the highest values of OxyP (Q4), a relative risk increase of 53%. The risk of having a SCORE2 > 10% was five times higher for those in Q1 (odds ratio: 4.96, 95% confidence interval: 2.76-8.93) vs. Q4 when adjusting for body mass index and high-sensitivity C-reactive protein. The OxyP was lower in individuals with CACS > 0 and in those with both carotid plaques and CACS > 0, compared with individuals without subclinical atherosclerotic burdens (87.5 +/- 5.6% and 86.9 +/- 6.0%, vs. 88.6 +/- 5.8%, P < 0.01). Conclusion In a population without CVD or diabetes mellitus, impaired microvascular function is associated with cardiovascular risk profiles such as higher SCORE2 risk and CACS. We suggest that OxyP may serve as a microcirculatory functional marker of subclinical atherosclerosis and CVD risk that is not detected by structural assessments.
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Jonasson, HannaLinköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten(Swepub:liu)hanka60
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Fredriksson, IngemarLinköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Perimed AB, Sweden(Swepub:liu)ingfr98
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Larsson, MarcusLinköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten(Swepub:liu)marla29
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Östgren, Carl JohanLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Vårdcentralen Ekholmen(Swepub:liu)caros18
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Strömberg, TomasLinköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten(Swepub:liu)tomst50
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Linköpings universitetAvdelningen för omvårdnad och reproduktiv hälsa
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In:European Journal of Preventive Cardiology: OXFORD UNIV PRESS2047-48732047-4881
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