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Zebrafish tumour xe...
Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer
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- Lindahl, Gabriel (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Fjellander, Sebastian (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,BioReper AB, Linkoping, Sweden
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- Selvaraj, Karthik (author)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten
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- Vildeval, Malin (author)
- BioReper AB, Linkoping, Sweden
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- Ali, Zaheer (author)
- BioReper AB, Linkoping, Sweden
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- Almter, Rusul (author)
- BioReper AB, Linkoping, Sweden
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- Erkstam, Anna (author)
- BioReper AB, Linkoping, Sweden
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- Rodriguez, Gabriela Vazquez (author)
- BioReper AB, Linkoping, Sweden
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- Abrahamsson, Annelie (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten
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- Rydmark Kersley, Asa (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Forum Östergötland,Region Östergötland, Kvinnokliniken US
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- Fahlgren, Anna (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,BioReper AB, Linkoping, Sweden
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- Kjölhede, Preben (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US
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- Linder, Stig (author)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten
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- Dabrosin, Charlotta (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Jensen, Lasse (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi,BioReper AB, Linkoping, Sweden
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(creator_code:org_t)
- NATURE PORTFOLIO, 2024
- 2024
- English.
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In: npj Precision Oncology. - : NATURE PORTFOLIO. - 2397-768X. ; 8:1
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Epithelial ovarian cancer (EOC) is the gynaecological malignancy with highest mortality. Although adjuvant treatment with carboplatin and paclitaxel leads to an objective response in similar to 80% of these patients, a majority will relapse within two years. Better methods for assessing long-term treatment outcomes are needed. To address this, we established safe and efficacious doses of carboplatin and paclitaxel using IGROV-1 zebrafish-CDX models. Then fluorescently-labelled cell suspensions from 83 tumour biopsies collected at exploratory laparotomy of women with suspected EOC were generated and 37 (45%) were successfully implanted in zebrafish larvae. Among these 19 of 27 pathology-confirmed EOC samples (70%) engrafted. These zebrafish patient-derived tumour xenograft (ZTX) models were treated with carboplatin or paclitaxel and tumour growth/regression and metastatic dissemination were recorded. In a subgroup of nine patients, four ZTX models regressed during carboplatin treatment. All four corresponding patients had > 24 months PFS. Furthermore, both ZTX models established from two patients having < 24 months PFS failed to regress during carboplatin treatment. Seven of eight models seeding < 6 metastatic cells were established from patients having > 24 months PFS. In eleven of fourteen patients, FIGO stage I + II or III tumours gave rise to ZTX models seeding < 4 or > 4 metastatic cells, respectively. In conclusion, ZTX models predicted patients having > 24 or < 24 months PFS, based on response/no response to carboplatin. Furthermore, high metastatic dissemination in ZTX models correlated to shorter PFS and more advanced disease at diagnosis. These preliminary results suggest that ZTX models could become a useful prognostic tool in EOC treatment planning.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lindahl, Gabriel
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Fjellander, Seba ...
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Selvaraj, Karthi ...
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Vildeval, Malin
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Ali, Zaheer
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Almter, Rusul
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show more...
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Erkstam, Anna
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Rodriguez, Gabri ...
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Abrahamsson, Ann ...
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Rydmark Kersley, ...
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Fahlgren, Anna
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Kjölhede, Preben
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Linder, Stig
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Dabrosin, Charlo ...
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Jensen, Lasse
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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npj Precision On ...
- By the university
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Linköping University