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Zebrafish tumour xe...
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Lindahl, GabrielLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
(author)
Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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NATURE PORTFOLIO,2024
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-201678
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201678URI
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https://doi.org/10.1038/s41698-024-00550-9DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|VINNOVA (Swedish Governmental Agency for Innovation Systems) [2017-01444, H2020-MSCA-RISE-Crystal3, LIO-934261]; VINNOVA
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Epithelial ovarian cancer (EOC) is the gynaecological malignancy with highest mortality. Although adjuvant treatment with carboplatin and paclitaxel leads to an objective response in similar to 80% of these patients, a majority will relapse within two years. Better methods for assessing long-term treatment outcomes are needed. To address this, we established safe and efficacious doses of carboplatin and paclitaxel using IGROV-1 zebrafish-CDX models. Then fluorescently-labelled cell suspensions from 83 tumour biopsies collected at exploratory laparotomy of women with suspected EOC were generated and 37 (45%) were successfully implanted in zebrafish larvae. Among these 19 of 27 pathology-confirmed EOC samples (70%) engrafted. These zebrafish patient-derived tumour xenograft (ZTX) models were treated with carboplatin or paclitaxel and tumour growth/regression and metastatic dissemination were recorded. In a subgroup of nine patients, four ZTX models regressed during carboplatin treatment. All four corresponding patients had > 24 months PFS. Furthermore, both ZTX models established from two patients having < 24 months PFS failed to regress during carboplatin treatment. Seven of eight models seeding < 6 metastatic cells were established from patients having > 24 months PFS. In eleven of fourteen patients, FIGO stage I + II or III tumours gave rise to ZTX models seeding < 4 or > 4 metastatic cells, respectively. In conclusion, ZTX models predicted patients having > 24 or < 24 months PFS, based on response/no response to carboplatin. Furthermore, high metastatic dissemination in ZTX models correlated to shorter PFS and more advanced disease at diagnosis. These preliminary results suggest that ZTX models could become a useful prognostic tool in EOC treatment planning.
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Fjellander, SebastianLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,BioReper AB, Linkoping, Sweden(Swepub:liu)sebjo77
(author)
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Selvaraj, KarthikLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten(Swepub:liu)karse35
(author)
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Vildeval, MalinBioReper AB, Linkoping, Sweden
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Ali, ZaheerBioReper AB, Linkoping, Sweden
(author)
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Almter, RusulBioReper AB, Linkoping, Sweden
(author)
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Erkstam, AnnaBioReper AB, Linkoping, Sweden
(author)
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Rodriguez, Gabriela VazquezBioReper AB, Linkoping, Sweden
(author)
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Abrahamsson, AnnelieLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten(Swepub:liu)annab29
(author)
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Rydmark Kersley, AsaLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Forum Östergötland,Region Östergötland, Kvinnokliniken US(Swepub:liu)asary59
(author)
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Fahlgren, AnnaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,BioReper AB, Linkoping, Sweden(Swepub:liu)annfa39
(author)
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Kjölhede, PrebenLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US(Swepub:liu)prekj14
(author)
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Linder, StigLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten(Swepub:liu)stili13
(author)
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Dabrosin, CharlottaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)chada67
(author)
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Jensen, LasseLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi,BioReper AB, Linkoping, Sweden(Swepub:liu)larje86
(author)
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Linköpings universitetAvdelningen för kirurgi, ortopedi och onkologi
(creator_code:org_t)
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Vildeval, Malin
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Ali, Zaheer
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Erkstam, Anna
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Kjölhede, Preben
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Linder, Stig
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